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Role of estrogen in postmenopausal depression

From the Department of Psychiatry and Department of Gynecology/Obstetrics, State University of New York at Buffalo, New York.
Supported in part by NIMH Grant RO1-MH 46101 and by the Nathan Cummings Foundation. Estraderm was supplied by the Ciba Geigy Co.
Address correspondence and reprint requests to Dr. Uriel Halbreich, Biobehavioral Program, School of Medicine and Biomedical Sciences, SUNY Clinical Center, BB170, 462 Grider Street, Buffalo, NY 14215.

Abstract.

Article abstract-Estrogen has been reported to improve the cognitive functioning of postmenopausal women. It is suggested that estrogen replacement therapy (ERT) might be beneficial for improvement of mood and cognition in menopausal women. We have shown that this improvement is selective and is probably more apparent in complex integrative functions. We have also shown that estrogen can augment serotonergic activity as well as some norepinephrine-related processes in postmenopausal women. Because of its effects on mood-related neurotransmitter processes, ERT might decrease vulnerability to depression and be effective as an adjunct therapy to prevent treatment nonresponse to conventional antidepressants.

NEUROLOGY 1997;48(Suppl 7): S16-S20