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Genesis of Alzheimer's disease

From the Department of Neurology, Case Western Reserve University, and the Alzheimer Center, University Hospitals of Cleveland, OH.
Supported by grant no. P50 AG08012 from the National Institute on Aging.
Address correspondence and reprint requests to Dr. Peter J. Whitehouse, Alzheimer Center, University Hospitals of Cleveland, 12200 Fairhill Road, Suite C222, Cleveland, OH 44120.

Abstract.

Article abstract-Our understanding of the pathogenesis of Alzheimer's disease (AD) has advanced rapidly, particularly in the area of genetics. Clinical trials of agents that offer the promise of going beyond symptomatic treatment to actually slowing the progression of disease, perhaps by enhancing the viability of neurons, are under way. Most of the ideas for therapeutic approaches that may slow progression of disease have come from a combination of epidemiologic and basic science observations. Anti-inflammatory agents, nicotine, estrogens, and free radical scavengers are major areas of inquiry. In addition to being a biological condition of considerable complexity, AD is also challenging from a social and cultural perspective. An appreciation of the changes occurring in our scientific and clinical environments may lead to building more effective bridges between science and society and to better diagnostic and therapeutic approaches to AD.

NEUROLOGY 1997;48(Suppl 7): S2-S7