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From the Department of Neurology, Emory University School of Medicine, Atlanta, GA.
Address correspondence and reprint requests to Dr. K. Sathian, Department of Neurology, WMRB-6000, Emory University School of Medicine, Atlanta, GA 30322.
We used gratings of alternating ridges and grooves in a quantitative psychophysical investigation of tactile perception in patients with Parkinson's disease (PD) and age-matched normal controls. The groove width required for threshold discrimination of grating orientation was 25% higher in the control subjects compared to younger individuals studied previously(p = 0.004), indicating a small but significant decline in tactile spatial acuity with age. Relative to age-matched controls, patients with PD showed a twofold increase in the tactile spatial threshold (p = 3.07 x 10-8), with somewhat greater impairment on the side more affected clinically (p = 0.03). Testing with the forearm prone, as compared to supine, produced a small improvement in the acuity of patients (p = 0.01) but not controls (p = 0.26). PD patients were also impaired in tactually discriminating grating roughness: their difference limens were over three times higher than those of controls(p = 5.74 x 10-5) for gratings differing in groove width, and over twice as high (p = 0.0003) for gratings differing in ridge width. We conclude that PD significantly impairs performance on these tactile tasks.
Supported in part through grants R29NS34111 (to K.S.) and RO1NS32047 (to M.R.D. and J.L.V.) from the NINDS.
Received September 5, 1996. Accepted in final form January 14, 1997.
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