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From the Departments of Internal Medicine (Dr. Straub), Neurology (Dr. Chofflon) and Radiology (Dr. Delavelle), University Hospital of Geneva, Switzerland.
Address correspondence and reprint requests to Dr. Judith Straub c/o Michel Chofflon, Clinique de Neurologie, Hôpital Cantonal Universitaire de Genève, rue Micheli-du Crest 24, CH-1211 Genève, Switzerland.
We describe a patient with acute disseminated encephalomyelitis (ADEM) who was treated with high-dose intravenous methylprednisolone 2 days after onset of neurologic symptoms. Despite poor prognostic factors and extensive white matter lesions, the patient recovered dramatically with no need for maintenance steroid therapy. This case report of fulminant ADEM treated successfully with early high-dose intravenous methylprednisolone, although uncontrolled, suggests that this agent should be studied in other cases.
Received December 6, 1996. Accepted in final form March 26, 1997.
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