HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Young, M. S. Articles by Friedman, W. A. Search for Related Content PubMed PubMed Citation Articles by Young, M. S. Articles by Friedman, W. A.

Stereotactic pallidotomy lengthens the transcranial magnetic cortical stimulation silent period in Parkinson's disease

From the Human Motor Physiology Laboratory (Drs. Young and Triggs), and Departments of Neurology (Drs. Young, Triggs, Bowers, and Greer) and Neurological Surgery (Dr. Friedman), University of Florida, Gainesville, FL.

Address correspondence and reprint requests to Dr. William J. Triggs, Department of Neurology, Box 100236 UFHSC, Gainesville, FL 32610-0236.

We compared the duration of the EMG cortical stimulation silent period(CSSP) elicited in abductor pollicis brevis using transcranial magnetic stimulation (TMS) before and after stereotactic unilateral globus pallidus internus pallidotomy (PAL) in 12 patients with Parkinson's disease. We used TMS stimulus intensities of 200, 150, 120, and 100% of motor evoked potential(MEP) threshold before and after (86 ± 25 days) PAL. PAL increased CSSP duration at stimulus intensities of 200% of MEP threshold in the hand contralateral to the stereotactic lesion. In a subset of five patients able to remain at rest during pre-PAL testing sessions, PAL decreased the resting MEP/M-wave area ratio in the hand contralateral to the lesion at a stimulus intensity of 120% of MEP threshold. PAL did not significantly modify the effects of TMS in the hand ipsilateral to the globus pallidus lesion. The results suggest that PAL improves the function of cortical motor inhibitory circuits in Parkinson's disease.

Supported by the National Parkinson Foundation.

Presented in part at the 26th annual meeting of the Society for Neuroscience, Washington, DC, November 16-21, 1996.

Received December 26, 1996. Accepted in final form June 13, 1997.

This article has been cited by other articles:

				A. A. Kuhn, B.-U. Meyer, T. Trottenberg, S. A. Brandt, G. H. Schneider, and A. Kupsch Modulation of motor cortex excitability by pallidal stimulation in patients with severe dystonia Neurology, March 11, 2003; 60(5): 768 - 774. [Abstract] [Full Text] [PDF]

				A. Gironell, J. Kulisevsky, B. P. Sedano, J. Molet, R. Chen, R. R. Garg, A. M. Lozano, and A. E. Lang Effects of internal globus pallidus stimulation on motor cortex excitability Neurology, February 26, 2002; 58(4): 669 - 670. [Full Text] [PDF]

				A V Chistyakov, J F Soustiel, H Hafner, M Trubnik, G Levy, and M Feinsod Excitatory and inhibitory corticospinal responses to transcranial magnetic stimulation in patients with minor to moderate head injury J. Neurol. Neurosurg. Psychiatry, May 1, 2001; 70(5): 580 - 587. [Abstract] [Full Text] [PDF]

				R. Chen, R. R. Garg, A. M. Lozano, and A. E. Lang Effects of internal globus pallidus stimulation on motor cortex excitability Neurology, March 27, 2001; 56(6): 716 - 723. [Abstract] [Full Text] [PDF]

				P. Limousin, R. G. Brown, M. Jahanshahi, P. Asselman, N. P. Quinn, D. Thomas, J. A. Obeso, and J. C. Rothwell The effects of posteroventral pallidotomy on the preparation and execution of voluntary hand and arm movements in Parkinson's disease Brain, February 1, 1999; 122(2): 315 - 327. [Abstract] [Full Text] [PDF]