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From the Department of Neurosciences, University of California San Diego, La Jolla, CA.
Address correspondence and reprint requests to Dr. Justin A. Zivin, Department of Neurosciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0624.
The duration of the window to treat acute cerebral ischemia has become an important question since the first effective drug for stroke victims has become available. Statistical analysis of relevant animal studies suggests that irreversible focal injury begins within a few minutes and is complete within about 6 hours. There will be substantial difficulties in attempting to obtain accurate estimates of the duration of ischemia that causes permanent damage in patients unless technical obstacles are overcome. Empirical estimates of the therapeutic window for stroke can be obtained from properly designed clinical trials, but optimal care will continue to necessitate urgent treatment.
Supported by National Institutes of Health grants PO1 NS28121 and RO1 NS23814, a Department of Veterans Affairs Merit Review Award, and Genentech, Inc.
Received July 17, 1997. Accepted in final form September 18, 1997.
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