| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Child Psychiatry Branch (Drs. Giedd, Rapoport, and Castellanos, and S.D. Hamburger), National Institute of Mental Health, Bethesda, MD; the Service de Pédiatrie 1 (Dr. Berquin), CHU Hôpital Nord, Amiens, France; the Department of Psychiatry (Dr. Jacobsen), Yale University School of Medicine, New Haven, CT; and the Department of Psychology (A.L. Krain), Temple University, Philadelphia, PA.
Address correspondence and reprint requests to Dr Castellanos, 10 Center Drive, Room 3N202, Bethesda, MD 20892-1600.
Clinical, neuroanatomic, neurobehavioral, and functional brain-imaging studies suggest a role for the cerebellum in cognitive functions, including attention. However, the cerebellum has not been systematically studied in attention-deficit hyperactivity disorder (ADHD). We quantified the cerebellar and vermal volumes, and the midsagittal areas of three vermal regions, from MRIs of 46 right-handed boys with ADHD and 47 matched healthy controls. Vermal volume was significantly less in the boys with ADHD. This reduction involved mainly the posterior inferior lobe (lobules VIII to X) but not the posterior superior lobe (lobules VI to VII). These results remained significant even after adjustment for brain volume and IQ. A cerebello-thalamo-prefrontal circuit dysfunction may subserve the motor control, inhibition, and executive function deficits encountered in ADHD.
Received February 26, 1997. Accepted in final form November 5, 1997.
This article has been cited by other articles:
|
|
 |
|
  M. Y. Kibby, J. B. Fancher, R. Markanen, and G. W. Hynd A Quantitative Magnetic Resonance Imaging Analysis of the Cerebellar Deficit Hypothesis of Dyslexia J Child Neurol, April 1, 2008; 23(4): 368 - 380. [Abstract] [PDF]
|
|
|
|
 |
|
 S. J. Suskauer, D. J. Simmonds, S. Fotedar, J. G. Blankner, J. J. Pekar, M. B. Denckla, and S. H. Mostofsky Functional magnetic resonance imaging evidence for abnormalities in response selection in attention deficit hyperactivity disorder: differences in activation associated with response inhibition but not habitual motor response. J. Cogn. Neurosci., March 1, 2008; 20(3): 478 - 493. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Limperopoulos and A. J. du Plessis Injury to the Developing Cerebellum: Mechanisms and Consequences NeoReviews, October 1, 2007; 8(10): e409 - e417. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Tavano, R. Grasso, C. Gagliardi, F. Triulzi, N. Bresolin, F. Fabbro, and R. Borgatti Disorders of cognitive and affective development in cerebellar malformations Brain, October 1, 2007; 130(10): 2646 - 2660. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Huber, K. Bradley, B. Spiegler, and M. Dennis Long-Term Neuromotor Speech Deficits in Survivors of Childhood Posterior Fossa Tumors: Effects of Tumor Type, Radiation, Age at Diagnosis, and Survival Years J Child Neurol, July 1, 2007; 22(7): 848 - 854. [Abstract] [PDF]
|
|
|
|
 |
|
 T. J. Spencer, J. Biederman, and E. Mick Attention-Deficit/Hyperactivity Disorder: Diagnosis, Lifespan, Comorbidities, and Neurobiology J. Pediatr. Psychol., July 1, 2007; 32(6): 631 - 642. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Lerner, A. Bagic, E. A. Boudreau, T. Hanakawa, F. Pagan, Z. Mari, W. Bara-Jimenez, M. Aksu, G. Garraux, J. M. Simmons, et al. Neuroimaging of neuronal circuits involved in tic generation in patients with Tourette syndrome Neurology, June 5, 2007; 68(23): 1979 - 1987. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Mackie, P. Shaw, R. Lenroot, R. Pierson, D. K. Greenstein, T. F. Nugent III, W. S. Sharp, J. N. Giedd, and J. L. Rapoport Cerebellar Development and Clinical Outcome in Attention Deficit Hyperactivity Disorder Am J Psychiatry, April 1, 2007; 164(4): 647 - 655. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Ventura, A. Presicci, T. Perniola, M. G. Campa, and L. Margari Mental Retardation and Epilepsy in Patients With Isolated Cerebellar Hypoplasia J Child Neurol, September 1, 2006; 21(9): 776 - 781. [Abstract] [PDF]
|
|
|
|
|
|
L. Furman What Is Attention-Deficit Hyperactivity Disorder (ADHD)? J Child Neurol, December 1, 2005; 20(12): 994 - 1002. [Abstract] [PDF]
|
|
|
|
 |
|
 C. Limperopoulos, J. S. Soul, H. Haidar, P. S. Huppi, H. Bassan, S. K. Warfield, R. L. Robertson, M. Moore, P. Akins, J. J. Volpe, et al. Impaired Trophic Interactions Between the Cerebellum and the Cerebrum Among Preterm Infants Pediatrics, October 1, 2005; 116(4): 844 - 850. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Vaidya, S. A. Bunge, N. M. Dudukovic, C. A. Zalecki, G. R. Elliott, and J. D.E. Gabrieli Altered Neural Substrates of Cognitive Control in Childhood ADHD: Evidence From Functional Magnetic Resonance Imaging Am J Psychiatry, September 1, 2005; 162(9): 1605 - 1613. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B Gottwald, B Wilde, Z Mihajlovic, and H M Mehdorn Evidence for distinct cognitive deficits after focal cerebellar lesions J. Neurol. Neurosurg. Psychiatry, November 1, 2004; 75(11): 1524 - 1531. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. K. S. Voeller Attention-Deficit Hyperactivity Disorder (ADHD) J Child Neurol, October 1, 2004; 19(10): 798 - 814. [Abstract] [PDF]
|
|
|
|
 |
|
 J. D. Schmahmann Disorders of the Cerebellum: Ataxia, Dysmetria of Thought, and the Cerebellar Cognitive Affective Syndrome J Neuropsychiatry Clin Neurosci, August 1, 2004; 16(3): 367 - 378. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. KING, J. TENNEY, V. ROSSI, L. COLAMUSSI, and S. BURDICK Neural Substrates Underlying Impulsivity Ann. N.Y. Acad. Sci., December 1, 2003; 1008(1): 160 - 169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Steinlin, S. Imfeld, P. Zulauf, E. Boltshauser, K.-O. Lovblad, A. R. Luthy, W. Perrig, and F. Kaufmann Neuropsychological long-term sequelae after posterior fossa tumour resection during childhood Brain, September 1, 2003; 126(9): 1998 - 2008. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Parmeggiani, A. Posar, M. C. Scaduto, S. Chiodo, and P. Giovanardi-Rossi Epilepsy, Intelligence, and Psychiatric Disorders in Patients With Cerebellar Hypoplasia J Child Neurol, January 1, 2003; 18(1): 1 - 4. [Abstract] [PDF]
|
|
|
|
 |
|
 F. X. Castellanos, P. P. Lee, W. Sharp, N. O. Jeffries, D. K. Greenstein, L. S. Clasen, J. D. Blumenthal, R. S. James, C. L. Ebens, J. M. Walter, et al. Developmental Trajectories of Brain Volume Abnormalities in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder JAMA, October 9, 2002; 288(14): 1740 - 1748. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Anderson, A. Polcari, S. B. Lowen, P. F. Renshaw, and M. H. Teicher Effects of Methylphenidate on Functional Magnetic Resonance Relaxometry of the Cerebellar Vermis in Boys With ADHD Am J Psychiatry, August 1, 2002; 159(8): 1322 - 1328. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Gogtay, J. Giedd, and J. L. Rapoport Brain Development in Healthy, Hyperactive, and Psychotic Children Arch Neurol, August 1, 2002; 59(8): 1244 - 1248. [Full Text] [PDF]
|
|
|
|
|
|
S. H. Mostofsky, A. G. Lasker, L. E. Cutting, M. B. Denckla, and D. S. Zee Oculomotor abnormalities in attention deficit hyperactivity disorder: A preliminary study Neurology, August 14, 2001; 57(3): 423 - 430. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. N. GIEDD, J. BLUMENTHAL, E. MOLLOY, and F. X. CASTELLANOS Brain Imaging of Attention Deficit/Hyperactivity Disorder Ann. N.Y. Acad. Sci., June 1, 2001; 931(1): 33 - 49. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. L. PEARL, R. E. WEISS, and M. A. STEIN Medical Mimics: Medical and Neurological Conditions Simulating ADHD Ann. N.Y. Acad. Sci., June 1, 2001; 931(1): 97 - 112. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. E. WOLF and J. WASSERSTEIN Adults ADHD: Concluding Thoughts Ann. N.Y. Acad. Sci., June 1, 2001; 931(1): 396 - 408. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. X. Castellanos, J. N. Giedd, P. C. Berquin, J. M. Walter, W. Sharp, T. Tran, A. C. Vaituzis, J. D. Blumenthal, J. Nelson, T. M. Bastain, et al. Quantitative Brain Magnetic Resonance Imaging in Girls With Attention-Deficit/Hyperactivity Disorder Arch Gen Psychiatry, March 1, 2001; 58(3): 289 - 295. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Courchesne, H. J. Chisum, J. Townsend, A. Cowles, J. Covington, B. Egaas, M. Harwood, S. Hinds, and G. A. Press Normal Brain Development and Aging: Quantitative Analysis at in Vivo MR Imaging in Healthy Volunteers Radiology, September 1, 2000; 216(3): 672 - 682. [Abstract] [Full Text]
|
|
|
|
|
|
M. Maschke, J. Drepper, K. Kindsvater, F. P Kolb, H.-C. Diener, and D. Timmann Fear conditioned potentiation of the acoustic blink reflex in patients with cerebellar lesions J. Neurol. Neurosurg. Psychiatry, March 1, 2000; 68(3): 358 - 364. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Nopoulos, S. Berg, F. X. Castellenos, A. Delgado, N. C. Andreasen, and J. L. Rapoport Developmental Brain Anomalies in Children With Attention-Deficit Hyperactivity Disorder J Child Neurol, February 1, 2000; 15(2): 102 - 108. [Abstract] [PDF]
|
|
|
|
|
|
M. Steinlin, M. Styger, and E. Boltshauser Cognitive impairments in patients with congenital nonprogressive cerebellar ataxia Neurology, September 1, 1999; 53(5): 966 - 966. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
