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NEUROLOGY 1998;50:1253-1259
© 1998 American Academy of Neurology

Human anterior intraparietal area subserves prehension

A combined lesion and functional MRI activation study

F. Binkofski, MD, C. Dohle, MPhil, S. Posse, PhD, K. M. Stephan, MD, H. Hefter, MD, PhD, R. J. Seitz, MD and H. J. Freund, MD

From the Department of Neurology (Drs. Binkofski, Stephan, Hefter, Seitz, and Freund, and C. Dohle), University of Düsseldorf; and the Institute of Medicine (Dr. Posse), Research Center Jülich GmbH, Jülich, Germany.

Address correspondence and reprint requests to Dr. Ferdinand Binkofski, Department of Neurology, University of Düsseldorf, Moorenstr. 5, 40225 Düsseldorf, Germany.

It has been shown in nonhuman primates that the posterior parietal cortex is involved in coordination of arm and eye movements in space, whereas the anterior intraparietal area in the anterior lateral bank of the intraparietal sulcus plays a crucial role in fine finger movements, such as grasping. In this study we show by optoelectronic movement recordings that patients with cortical lesions involving the anterior lateral bank of the intraparietal sulcus have selective deficits in the coordination of finger movements required for object grasping, whereas reaching is much less disturbed. Patients with parietal lesions sparing the cortex lining the anterior intraparietal sulcus showed intact grasping behavior. Complementary evidence was obtained from functional MRI in normal control subjects showing a specific activation of the anterior lateral bank of the intraparietal sulcus during grasping. In conclusion, this combined lesion and activation study suggests that the anterior lateral bank of the intraparietal sulcus, possibly including the human homologue of the anterior intraparietal area, mediates the processing of sensorimotor integration of precisely tuned finger movements in humans.

Supported by grants from the Deutsche Forschungsgemeinschaft (SFB 194) and the European Science Foundation grant (to F.B.).

Received April 23, 1997. Accepted in final form December 11, 1997.




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