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NEUROLOGY 1998;50:1496-1498
© 1998 American Academy of Neurology

Motor slowing precedes cognitive impairment in the oldest old

R. Camicioli, MD, D. Howieson, PhD, B. Oken, MD, G. Sexton, PhD and J. Kaye, MD

From the Department of Neurology, Oregon Health Sciences University, and the Veteran's Affairs Medical Center, Portland, OR.

Address correspondence and reprint requests to Dr. Richard Camicioli, Aging and Alzheimer Disease Center, L226, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201-3098.

Eighty-five healthy elderly subjects were prospectively evaluated for 3 years to determine motor differences between those who remain cognitively intact and those who developed cognitive impairment during prospective follow-up. The 18 subjects who developed cognitive impairment had slower finger tapping and took longer to walk 30 feet before or at the time of cognitive impairment. Coordination was more impaired and steps, but not balance, deteriorated more rapidly, independent of other variables.

Supported by grants from the Department of Veterans Affairs and the National Institute on Aging (AG08017) and the Alzheimer Research Alliance of Oregon.

Presented in part at the 48th annual meeting of the American Academy of Neurology, San Francisco, 1996.

Received October 7, 1996. Accepted in final form December 20, 1997.




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