Neurology, Vol 50, Issue 6 1857-1859, Copyright © 1998 by American Academy of Neurology

ARTICLES

Hemopericardium and cardiac tamponade after thrombolysis for acute ischemic stroke

SE Kasner, CE Villar-Cordova, D Tong and JC Grotta
University of Pennsylvania Medical Center, Philadelphia, USA.

Hemorrhage is the major complication of IV recombinant tissue plasminogen activator (rt-PA) treatment for stroke. We report three patients with mild or indistinct cardiac symptoms prior to thrombolysis in whom hemodynamically significant cardiac tamponade occurred after treatment with rt-PA. Acute ischemic stroke patients may have undetected myocardial or pericardial disease that may pose a risk for hemopericardium and life-threatening tamponade after treatment with rt- PA.

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