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Magnetic resonance imaging of muscle in amyotrophic lateral sclerosis

From the Departments of Neurology (Drs. Bryan and Barohn, and L.L. Herbelin), Academic Computing Services (Dr. Reisch), and Radiology (Drs. McDonald and Fleckenstein), The University of Texas Southwestern Medical Center at Dallas, TX.

Address correspondence and reprint requests to Dr. Wilson W. Bryan, Department of Neurology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235-8897.

Objective: To characterize leg muscle abnormalities in patients with ALS using MRI, and to correlate MRI with standard neurologic measures of motor neuron dysfunction.

Methods: Eleven ALS patients were studied twice (once at baseline and again after 4 months) and compared with eight normal control subjects. MRI data of the lower extremities were compared with tibialis anterior compound muscle action potential amplitude (CMAPa) and foot dorsiflexion maximal voluntary isometric contraction (MVIC).

Results: Muscle MRI was abnormal by visual inspection in six of 11 patients. The mean muscle T1 time and muscle volume were not different in patients compared with normal control subjects (p > 0.1). However, the mean T2 times were increased in the patients compared with normal control subjects(p = 0.009). T1 times did not correlate with CMAPa or MVIC. Muscle volume correlated with MVIC (r = 0.73 to 0.78, p < 0.02) but not with CMAPa (p > 0.05). There was a strong negative correlation (r < -0.8, p 0.01) between muscle T2 time and MVIC and CMAPa. Also, the change in T2 relaxation time correlated with the change in CMAPa as the disease progressed (r =-0.63, p = 0.037).

Conclusion: Of the MRI characteristics studied, T2 relaxation time was the best indicator of motor neuron dysfunction and may have a role in objective evaluation of motor neuron dysfunction.

Presented in part at the seventh International Symposium on ALS/MND, Chicago, IL, November 11-13, 1996.

Received November 3, 1997. Accepted in final form March 11, 1998.

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