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NEUROLOGY 1998;51:17-19
© 1998 American Academy of Neurology

Trigeminal neuralgia

Mechanisms of treatment

Richard B. Tenser, MD

From Penn State University College of Medicine, Penn State Geisinger Health System, Hershey, PA.

Address correspondence and reprint requests to Dr. Richard B. Tenser, Penn State University College of Medicine, 500 University Drive, Hershey, PA 17033.

Background: Mechanisms of the surgical treatment of trigeminal neuralgia are considered.

Results: Trigeminal neuralgia is effectively treated by microvascular decompression(MVD) and other surgical procedures. These procedures often cause reactivation of herpes simplex virus (HSV), which is latent in trigeminal ganglion neurons.

Conclusion: MVD and other surgical procedures alter ganglion neuron transcription, as indicated by HSV reactivation. Controlled injury of the trigeminal root-ganglion probably occurs with the disparate surgical procedures, and this is likely the means of their effectiveness.

Received January 12, 1998. Accepted in final form March 25, 1998.




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