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NEUROLOGY 1998;51:274-276
© 1998 American Academy of Neurology

Serotonin syndrome induced by transitioning from phenelzine to venlafaxine: Four patient reports

S. Diamond, MD, B. J. Pepper, MD, M. L. Diamond, MD, F. G. Freitag, DO, G. J. Urban, MD and A. K. Erdemoglu, MD

From the Diamond Headache Clinic, Chicago, IL.

Address correspondence and reprint to Dr. Seymour Diamond, Diamond Headache Clinic, 467 West Deming Place, Suite 500 Chicago, IL 60614-1726.

With the use of the newer antidepressants beyond the traditional tricyclics and monoamine oxidase inhibitors, newer options in headache prophylaxis are provided as well as the potential for undesirable and even potentially life-threatening interactions between medications. In this article, four patient reports of a specific interaction-the serotonin syndrome-are presented. These events resulted from transitioning headache patients from an older antidepressant (phenelzine) to a newer antidepressant(venlafaxine).

Received May 30, 1996. Accepted in final form February 26, 1998.






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