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NEUROLOGY 1998;51:283-285
© 1998 American Academy of Neurology

Early morning dystonia in Parkinson's disease

L. J. Currie, PhD, RN, M. B. Harrison, MD, J. M. Trugman, MD, J. P. Bennett, Jr., MD and G. F. Wooten, MD

From the Department of Neurology, University of Virginia Health Sciences Center, Charlottesville, VA.

Address correspondence and reprint requests to Dr. Lillian J. Currie, PhD, RN, Department of Neurology, Box 394, University of Virginia Health Sciences Center, Charlottesville, VA 22908.

We interviewed 383 patients with PD regarding disease onset and medication history and evaluated them using the Unified Parkinson's Disease Rating Scale. Sixteen percent of the sample reported the occurrence of early morning dystonia (EMD). Patients with EMD had been taking levodopa for a longer time, were taking higher daily levodopa doses, demonstrated more disability in carrying out their activities of daily living, exhibited dystonia more often before initiation of levodopa treatment, and experienced more peak-dose and diphasic dyskinesias with levodopa therapy.

Supported by an American Parkinson's Disease Association Center of Excellence Award and the Harrison Endowment of the University of Virginia.

Received November 6, 1997. Accepted in final form January 16, 1998.




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