| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Radiology and Physics Unit (Drs. Connelly, Porter, and Gadian), Institute of Child Health, University College London Medical School; NMR Unit (Drs. Connelly, Van Paesschen, Porter, Johnson, and Gadian), Department of Radiology, Great Ormond Street Hospital for Children; Epilepsy Research Group (Drs. Van Paesschen and Duncan), University Department of Clinical Neurology, National Hospital for Neurology and Neurosurgery, London, UK.
Address correspondence and reprint requests to Dr. Alan Connelly, MR2, Department of Radiology, Great Osmond Street Hospital for Children, Great Ormond Street, London WC1N 3JH, UK.
Objective: To determine the 1H MRS findings in patients with intractable temporal lobe epilepsy (TLE) who had no detectable abnormality on either qualitative or quantitative MRI.
Background: Previous work has indicated that 
20% of patients with TLE remain MRI negative after extensive qualitative and quantitative investigation. Single-voxel 1H MRS provides a means of identifying potentially diffuse disease.
Methods: Seven patients with intractable TLE, normal routine MRI, normal hippocampal volumes, and normal hippocampal and amygdala quantitative T2 values underwent single-voxel 1H MRS of the medial temporal lobes. The results are compared with those from 13 control subjects and 15 patients with evidence of hippocampal sclerosis (HS).
Results: The ratio N-acetylaspartate/(cholinecreatine + phosphocreatine) was abnormally low in five of the seven MRI-negative patients. In two of these patients, the ratios were low bilaterally. The observed MRS ratios in the MRI-negative group with abnormal EEG were similar to those from temporal lobes ipsilateral to HS, suggesting the presence of widespread or diffuse disease of a similar degree in both groups.
Conclusions: These results demonstrate that MRS can provide evidence of temporal lobe abnormalities in TLE patients who show no abnormality on extensive MRI investigation.
Supported in part by the Wellcome Trust and Action Research.
Received November 10, 1997. Accepted in final form March 11, 1998.
This article has been cited by other articles:
|
|
 |
|
  T. Bartsch, K. Alfke, S. Wolff, A. Rohr, O. Jansen, and G. Deuschl Focal MR spectroscopy of hippocampal CA-1 lesions in transient global amnesia Neurology, March 25, 2008; 70(13): 1030 - 1035. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J M Dickson, I D Wilkinson, S J L Howell, P D Griffiths, and R A Grunewald Idiopathic generalised epilepsy: a pilot study of memory and neuronal dysfunction in the temporal lobes, assessed by magnetic resonance spectroscopy J. Neurol. Neurosurg. Psychiatry, July 1, 2006; 77(7): 834 - 840. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Bernasconi, N. Bernasconi, J. Natsume, S. B. Antel, F. Andermann, and D. L. Arnold Magnetic resonance spectroscopy and imaging of the thalamus in idiopathic generalized epilepsy Brain, November 1, 2003; 126(11): 2447 - 2454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F Zubler, M Seeck, T Landis, F Henry, and F Lazeyras Contralateral medial temporal lobe damage in right but not left temporal lobe epilepsy: a 1H magnetic resonance spectroscopy study J. Neurol. Neurosurg. Psychiatry, September 1, 2003; 74(9): 1240 - 1244. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Duncan Seizure-induced neuronal injury: Human data Neurology, November 12, 2002; 59(90095): S15 - 20. [Abstract] [Full Text]
|
|
|
|
|
|
S. P. Miller, J. Weiss, A. Barnwell, D. M. Ferriero, B. Latal-Hajnal, A. Ferrer-Rogers, N. Newton, J. C. Partridge, D. V. Glidden, D. B. Vigneron, et al. Seizure-associated brain injury in term newborns with perinatal asphyxia Neurology, February 26, 2002; 58(4): 542 - 548. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C.W. Brooks, N. Roberts, G. J. Kemp, M. A. Gosney, M. Lye, and G. H. Whitehouse A Proton Magnetic Resonance Spectroscopy Study of Age-related Changes in Frontal Lobe Metabolite Concentrations Cereb Cortex, July 1, 2001; 11(7): 598 - 605. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Capizzano, P. Vermathen, K. D. Laxer, G. R. Ende, D. Norman, H. Rowley, G. B. Matson, A. A. Maudsley, M. R. Segal, and M. W. Weiner Temporal Lobe Epilepsy: Qualitative Reading of Radiology, January 1, 2001; 218(1): 144 - 151. [Abstract] [Full Text]
|
|
|
|
|
|
F. Lazeyras, O. Blanke, I. Zimine, J. Delavelle, S. H. Perrig, and M. Seeck MRI, 1H-MRS, and functional MRI during and after prolonged nonconvulsive seizure activity Neurology, December 12, 2000; 55(11): 1677 - 1682. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Wyss and R. Kaddurah-Daouk Creatine and Creatinine Metabolism Physiol Rev, July 1, 2000; 80(3): 1107 - 1213. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
