| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Department of Neurology (Drs. Sheikh, Ho, Cornblath, McKhann, and Griffin), Johns Hopkins University School of Medicine, Baltimore; the Johns Hopkins University Zanvyl Krieger Mind-Brain Institute (Dr. McKhann), Baltimore, MD; the Departments of Pathology and Laboratory Medicine (Dr. Nachamkin and H. Ung) and Neurology (Dr. Asbury), University of Pennsylvania School of Medicine, Philadelphia, PA; the Department of Neurology (H.J. Willison and J. Veitch), Institute of Neurological Sciences, University of Glasgow, Scotland, UK; Centers for Disease Control and Prevention (M. Nicholson), Atlanta, GA; the Department of Neurology (Dr. Li), Second Teaching Hospital, Hebei Medical School, Shijiazhuang; Department of Neurology (Dr. Wu), Beijing Children's Hospital, Beijing; and the Department of Infectious Diseases (Dr. Shen), First Teaching Hospital, Beijing Medical University, Beijing, People's Republic of China.
Address correspondence and reprint requests to Dr Sheikh, Department of Neurology, Johns Hopkins University School of Medicine, Pathology 509, 600 N. Wolfe Street, Baltimore, MD 21287.
Objective: This study was designed to determine if the presence of specific ganglioside-like moieties in Campylobacter lipopolysaccharides(LPSs) is related to the development of Guillain-Barré syndrome (GBS), and to discover how frequently such moieties, including GM1, are present in these LPSs.
Methods: We studied Campylobacter isolates and sera from seven patients with GBS (five acute motor axonal neuropathy, one acute inflammatory demyelinating polyneuropathy, and one Fisher's syndrome), and compared them with similar specimens from patients with Campylobacter enteritis alone.
Results: All GBS patients had antiganglioside antibodies. Anti-GM1 and anti-GD1a titers were significantly elevated in post-Campylobacter GBS, both axonal and demyelinating, compared with normal control subjects or those with uncomplicated Campylobacter diarrhea. Campylobacter isolated from patients with GBS and with enteritis alone had similar ganglioside-like moieties.
Conclusions: These results indicate that patients who develop GBS respond differently to the ganglioside-like epitopes on Campylobacter than do non-GBS diarrhea patients. Our findings support a role for host susceptibility as a determinant for the outcome following Campylobacter infection. These findings have important implications for the development of vaccines against Campylobacter jejuni.
Supported in part by National Institutes of Health grants NS-34846 and NS-31528.
Received December 3, 1997. Accepted in final form February 22, 1998.
This article has been cited by other articles:
|
|
 |
|
  K. Kaida, T. Ariga, and R. K Yu Antiganglioside antibodies and their pathophysiological effects on Guillain-Barre syndrome and related disorders--A review Glycobiology, July 1, 2009; 19(7): 676 - 692. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Nachamkin, P. A. Barbosa, H. Ung, C. Lobato, A. G. Rivera, P. Rodriguez, A. G. Briseno, L. M. Cordero, L. G. Perea, J. C. Perez, et al. Patterns of Guillain-Barre syndrome in children: Results from a Mexican population Neurology, October 23, 2007; 69(17): 1665 - 1671. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. K. Yu, S. Usuki, and T. Ariga Ganglioside Molecular Mimicry and Its Pathological Roles in Guillain-Barre Syndrome and Related Diseases Infect. Immun., December 1, 2006; 74(12): 6517 - 6527. [Full Text] [PDF]
|
|
|
|
|
|
S. Kuwabara, K. Ogawara, S. Misawa, M. Koga, M. Mori, A. Hiraga, T. Kanesaka, T. Hattori, and N. Yuki Does Campylobacter jejuni infection elicit "demyelinating" Guillain-Barre syndrome? Neurology, August 10, 2004; 63(3): 529 - 533. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. E. Magira, M. Papaioakim, I. Nachamkin, A. K. Asbury, C. Y. Li, T. W. Ho, J. W. Griffin, G. M. McKhann, and D. S. Monos Differential Distribution of HLA-DQ{beta}/DR{beta} Epitopes in the Two Forms of Guillain-Barre Syndrome, Acute Motor Axonal Neuropathy and Acute Inflammatory Demyelinating Polyneuropathy (AIDP): Identification of DQ{beta} Epitopes Associated with Susceptibility to and Protection from AIDP J. Immunol., March 15, 2003; 170(6): 3074 - 3080. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Nachamkin, J. Liu, M. Li, H. Ung, A. P. Moran, M. M. Prendergast, and K. Sheikh Campylobacter jejuni from Patients with Guillain-Barre Syndrome Preferentially Expresses a GD1a-Like Epitope Infect. Immun., September 1, 2002; 70(9): 5299 - 5303. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. W. Ang, J. D. Laman, H. J. Willison, E. R. Wagner, H. P. Endtz, M. A. De Klerk, A. P. Tio-Gillen, N. Van den Braak, B. C. Jacobs, and P. A. V. Doorn Structure of Campylobacter jejuni Lipopolysaccharides Determines Antiganglioside Specificity and Clinical Features of Guillain-Barre and Miller Fisher Patients Infect. Immun., March 1, 2002; 70(3): 1202 - 1208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. W. Ang, M. A. De Klerk, H. P. Endtz, B. C. Jacobs, J. D. Laman, F. G. A. van der Meche, and P. A. van Doorn Guillain-Barre Syndrome- and Miller Fisher Syndrome-Associated Campylobacter jejuni Lipopolysaccharides Induce Anti-GM1 and Anti-GQ1b Antibodies in Rabbits Infect. Immun., April 1, 2001; 69(4): 2462 - 2469. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Prendergast, T. U. Kosunen, and A. P. Moran Development of an Immunoassay for Rapid Detection of Ganglioside GM1 Mimicry in Campylobacter jejuni Strains J. Clin. Microbiol., April 1, 2001; 39(4): 1494 - 1500. [Abstract] [Full Text]
|
|
|
|
|
|
R.D.M. Hadden, H. Karch, H.-P. Hartung, J. Zielasek, B. Weissbrich, J. Schubert, A. Weishaupt, D.R. Cornblath, A.V. Swan, R.A.C. Hughes, et al. Preceding infections, immune factors, and outcome in Guillain-Barre syndrome Neurology, March 27, 2001; 56(6): 758 - 765. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Seneviratne Guillain-Barre syndrome Postgrad. Med. J., December 1, 2000; 76(902): 774 - 782. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. M. Prendergast and A. P. Moran Review: Lipopolysaccharides in the development of the Guillain-Barre syndrome and Miller Fisher syndrome forms of acute inflammatory peripheral neuropathies Innate Immunity, October 1, 2000; 6(5): 341 - 359. [Abstract] [PDF]
|
|
|
|
|
|
C. W. Ang, B. C. Jacobs, A. H. Brandenburg, J. D. Laman, F. G. A. van der Meche, A. D. M. E. Osterhaus, and P. A. van Doorn Cross-reactive antibodies against GM2 and CMV-infected fibroblasts in Guillain-Barre syndrome Neurology, April 11, 2000; 54(7): 1453 - 1458. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. K. Asbury New Concepts of Guillain-Barre Syndrome J Child Neurol, March 1, 2000; 15(3): 183 - 191. [Abstract] [PDF]
|
|
|
|
|
|
T. M. Wassenaar, B. N. Fry, A. J. Lastovica, J. A. Wagenaar, P. J. Coloe, and B. Duim Genetic Characterization of Campylobacter jejuni O:41 Isolates in Relation with Guillain-Barre Syndrome J. Clin. Microbiol., February 1, 2000; 38(2): 874 - 876. [Abstract] [Full Text]
|
|
|
|
|
|
J. L. Lu, K. A. Sheikh, H. S. Wu, J. Zhang, Z. F. Jiang, D. R. Cornblath, G. M. McKhann, A. K. Asbury, J. W. Griffin, and T. W. Ho Physiologic-pathologic correlation in Guillain-Barre syndrome in children Neurology, January 11, 2000; 54(1): 33 - 33. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. G. Holloway and T. E. Feasby To test or not to test? Neurology, December 1, 1999; 53(9): 1905 - 1905. [Full Text] [PDF]
|
|
|
|
 |
|
 A. H. Ropper and M. Victor Influenza Vaccination and the Guillain-Barre Syndrome N. Engl. J. Med., December 17, 1998; 339(25): 1845 - 1846. [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
