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NEUROLOGY 1998;51:603-605
© 1998 American Academy of Neurology

A loss of functional spinal alpha motor neurons in amyotrophic lateral sclerosis

Keisuke Arasaki, MD, PhD and Mitsuyuki Tamaki, MD, PhD

From the Department of Neurology, NTT Kanto Teishin Hospital, Tokyo, Japan.

Address correspondence and reprint requests to Dr. Keisuke Arasaki, EMG/EEG Laboratory, Department of Neurology, NTT Kanto Teishin Hospital, 5-9-22 Higashi-Gotanda, Shinagawa-ku, Tokyo, 141-0022 Japan.

We obtained motor unit number estimates (MUNEs) of the hypothenar and the extensor digitorum brevis muscles in ALS patients by our new technique. One year after symptom onset, the MUNEs had decreased to ±30% of normal. Accordingly, we suggest that 70% of functional spinal alpha motor neurons are lost in the first post-onset year in ALS.

Received November 3, 1997. Accepted in final form March 6, 1998.






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