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NEUROLOGY 1998;51:617-619
© 1998 American Academy of Neurology

An unusual case of Creutzfeldt-Jakob disease

F.J.G. Vingerhoets, MD, I. Hegyi, MD, A. Aguzzi, MD, P. Myers, MD, G. Pizzolato, MD and T. Landis, MD

From the Clinic of Neurology (Drs. Vingerhoets, Myers, and Landis) and Department of Pathology (Neuropathology Unit) (Dr. Pizzolato), University Hospital of Geneva, Switzerland; and the Institute of Neuropathology(Drs. Hegyi and Aguzzi), Department of Pathology, University of Zürich, Switzerland.

Address correspondence and reprint requests to Dr. Vingerhoets, Service de Neurologie-BH 13, CHUV, 1011 Lausanne, Switzerland.

A patient with histopathologically verified sporadic Creutzfeldt-Jakob disease (CJD) presented initially with diplopia, sleep disturbances, and L-dopa-responsive parkinsonism. After more than a year of slow progression, he did not become demented, and failed to fulfill the clinical criteria for possible CJD. No clinical examinations currently proposed to detect CJD showed the disease. CJD should be in the differential diagnosis of "parkinson plus" syndromes until a different etiology has been found or a histopathologic examination performed.

Supported in part by grant 0032-051090 from the Swiss National Science Foundation.

Received January 21, 1998. Accepted in final form April 3, 1998.






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