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NEUROLOGY 1998;51:629-631
© 1998 American Academy of Neurology

Disseminated intravascular coagulation and status epilepticus

A. Felcher, MD, C. Commichau, MD, Q. Cao, MD, PhD, M. J. Brown, BS, A. Torres, MD and C. W. Francis, MD

From the Departments of Medicine (Drs. Felcher, Torres, Brown, and Francis), Neurology (Dr. Commichau), and Pathology (Dr. Cao), University of Rochester School of Medicine & Dentistry, Rochester, NY.

Address correspondence and reprint requests to Dr Francis, Vascular Medicine Unit, Box 610, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14610.

Status epilepticus has been associated with disseminated intravascular coagulation (DIC), but little is known regarding the pathogenesis of this uncommon association. We describe a 41-year-old woman with status epilepticus resulting in death in whom laboratory data demonstrated profound activation of the coagulation and fibrinolytic systems; autopsy findings were consistent with DIC. The occurrence of DIC in status epilepticus may be related to widespread endothelial damage secondary to seizure-induced hyperpyrexia. Body temperature should be closely monitored in patients with prolonged seizures.

Supported in part by Grant No. HL-30616 from the National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD.

Received September 25, 1997. Accepted in final form March 27, 1998.




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[Abstract] [Full Text] [PDF]


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