| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Department of Neurology (Drs. Fassbender, Schwartz, Mielke, and Hennerici, and A. Ragoschke and A. Paulig) and Internal Medicine (Dr. Rossol), University of Heidelberg, Klinikum Mannheim, Germany.
Address correspondence and reprint requests to Dr. Klaus Fassbender, Department of Neurology, Klinikum Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer, D-68135 Mannheim, Germany.
Objective: The p40 subunit of interleukin (IL)-12 was recently demonstrated in active lesions in MS. We tested whether the p40 subunit of IL-12 can also be detected in CSF and serum of patients with this disease and, if so, whether release is associated with inflammatory disease activity.
Results: This study demonstrates an increased (up to 1,000-fold) compartmentalized release of the p40 subunit but not of the heterodimer p70 in MS. Release of IL-12p40 correlated with classic markers of CNS inflammation (CSF cell counts, immunoglobulin G index) and was significantly increased in patients with gadolinium-enhancing plaques on MRI. Moreover, release of IL-12p40 was associated with CSF levels of myelin basic protein as a measure of myelin degradation.
Conclusion: These results suggest a role of IL-12p40 in the pathophysiology of MS.
Supported by the Forschungsfond Mannheim, University of Heidelberg.
Received November 24, 1997. Accepted in final form May 5, 1998.
This article has been cited by other articles:
|
|
 |
|
  S. Brahmachari and K. Pahan Suppression of Regulatory T Cells by IL-12p40 Homodimer via Nitric Oxide J. Immunol., August 1, 2009; 183(3): 2045 - 2058. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mondal, A. Roy, and K. Pahan Functional Blocking Monoclonal Antibodies against IL-12p40 Homodimer Inhibit Adoptive Transfer of Experimental Allergic Encephalomyelitis J. Immunol., April 15, 2009; 182(8): 5013 - 5023. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Kroenke, T. J. Carlson, A. V. Andjelkovic, and B. M. Segal IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition J. Exp. Med., July 7, 2008; 205(7): 1535 - 1541. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Braitch, R. Nunan, G. Niepel, L. J. Edwards, and C. S. Constantinescu Increased Osteopontin Levels in the Cerebrospinal Fluid of Patients With Multiple Sclerosis Arch Neurol, May 1, 2008; 65(5): 633 - 635. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Aranami, S. Miyake, and T. Yamamura Differential Expression of CD11c by Peripheral Blood NK Cells Reflects Temporal Activity of Multiple Sclerosis J. Immunol., October 15, 2006; 177(8): 5659 - 5667. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Ishizu, M. Osoegawa, F.-J. Mei, H. Kikuchi, M. Tanaka, Y. Takakura, M. Minohara, H. Murai, F. Mihara, T. Taniwaki, et al. Intrathecal activation of the IL-17/IL-8 axis in opticospinal multiple sclerosis Brain, May 1, 2005; 128(5): 988 - 1002. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-M. Huang, X. Liu, K. Steffensen, A. Sanna, G. Arru, M. L. Fois, G. Rosati, S. Sotgiu, and H. Link Immunological heterogeneity of multiple sclerosis in Sardinia and Sweden Multiple Sclerosis, February 1, 2005; 11(1): 16 - 23. [Abstract] [PDF]
|
|
|
|
|
|
H. P. M. Brok, M. van Meurs, E. Blezer, A. Schantz, D. Peritt, G. Treacy, J. D. Laman, J. Bauer, and B. A. 't Hart Prevention of Experimental Autoimmune Encephalomyelitis in Common Marmosets Using an Anti-IL-12p40 Monoclonal Antibody J. Immunol., December 1, 2002; 169(11): 6554 - 6563. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V Ozenci, M Kouwenhoven, and H Link Cytokines in multiple sclerosis: methodological aspects and pathogenic implications Multiple Sclerosis, October 1, 2002; 8(5): 396 - 404. [Abstract] [PDF]
|
|
|
|
|
|
C. Natarajan and J. J. Bright Curcumin Inhibits Experimental Allergic Encephalomyelitis by Blocking IL-12 Signaling Through Janus Kinase-STAT Pathway in T Lymphocytes J. Immunol., June 15, 2002; 168(12): 6506 - 6513. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Alleva, E. B. Johnson, J. Wilson, D. I. Beller, and P. J. Conlon SJL and NOD macrophages are uniquely characterized by genetically programmed, elevated expression of the IL-12(p40) gene, suggesting a conserved pathway for the induction of organ-specific autoimmunity J. Leukoc. Biol., March 1, 2001; 69(3): 440 - 448. [Abstract] [Full Text]
|
|
|
|
|
|
S. Ehlers, S. Kutsch, E. M. Ehlers, J. Benini, and K. Pfeffer Lethal Granuloma Disintegration in Mycobacteria-Infected TNFRp55-/- Mice Is Dependent on T Cells and IL-12 J. Immunol., July 1, 2000; 165(1): 483 - 492. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Wang, M. Chen, K. P. Wandinger, G. Williams, and S. Dhib-Jalbut IFN-{beta}-1b Inhibits IL-12 Production in Peripheral Blood Mononuclear Cells in an IL-10-Dependent Mechanism: Relevance to IFN-{beta}-1b Therapeutic Effects in Multiple Sclerosis J. Immunol., July 1, 2000; 165(1): 548 - 557. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Pahan, F. G. Sheikh, X. Liu, S. Hilger, M. McKinney, and T. M. Petro Induction of Nitric-oxide Synthase and Activation of NF-kappa B by Interleukin-12 p40 in Microglial Cells J. Biol. Chem., March 9, 2001; 276(11): 7899 - 7905. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
