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NEUROLOGY 1998;51:1172-1175
© 1998 American Academy of Neurology

Lamotrigine-associated anticonvulsant hypersensitivity syndrome

Raymond G. Schlienger, PhD, Sandra R. Knowles, BScPhm and Neil H. Shear, MD, FRCPC

From the Divisions of Clinical Pharmacology (Drs. Schlienger and Shear, and S.R. Knowles) and Dermatology (Dr. Shear); Departments of Medicine (Drs. Schlienger and Shear, and S.R. Knowles), Pharmacology (Dr. Shear), and Pharmacy (S.R. Knowles and Dr. Shear); and the Glaxo Wellcome Sunnybrook Drug Safety Clinic (S.R. Knowles and Dr. Shear), Sunnybrook Health Science Centre, University of Toronto, Canada.

Address correspondence and reprint requests to Dr. Neil H. Shear, Div. of Clinical Pharmacology, Rm. E-240, Sunnybrook Health Science Centre, 2075 Bayview Avenue, Toronto, ONT, Canada M4N 3M5.

We systematically reviewed and analyzed published and unpublished cases of lamotrigine-associated adverse drug reactions consistent with the features of the anticonvulsant hypersensitivity syndrome (AHS) to identify characteristics of the syndrome. We identified 26 cases (mean age, 28 ± 18 years; range, 3.5 to 74 years; 54% female), of which nine were published. The characteristics of the syndrome associated with lamotrigine are comparable to AHS induced by older aromatic anticonvulsants.

The information obtained from the WHO is not homogenous, at least with respect to origin or likelihood that the pharmaceutical product caused the adverse reaction. The opinions expressed in this article are those of the authors and do not represent the opinion of the WHO.

R.G.S. was supported by a grant from the Swiss National Science Foundation.




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