Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Semah, F.
Right arrow Articles by Baulac, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Semah, F.
Right arrow Articles by Baulac, M.
NEUROLOGY 1998;51:1256-1262
© 1998 American Academy of Neurology

Is the underlying cause of epilepsy a major prognostic factor for recurrence?

F. Semah, MD, M.-C. Picot, MD, C. Adam, MD, D. Broglin, MD, A. Arzimanoglou, MD, B. Bazin, MD, D. Cavalcanti, MD and M. Baulac, MD

From the Epilepsy Unit (Drs. Semah, Adam, Broglin, Arzimanoglou, Bazin, Cavalcanti, and Baulac), Clinique P. Castaigne, Hôpital de la Salpêtrière, Paris; SHFJ (Dr. Semah), CEA, Orsay; and the Department of Medical Information (Dr. Picot), Hôpital Lapeyronie, Montpellier, France.

Address correspondence and reprint requests to Dr. Franck Semah, SHFJ, CEA, 4 Place du Général Leclerc, 91401 Orsay Cedex, France.

Background: We investigated the prognostic value of the type of epilepsies and epileptic syndromes for seizure recurrence. In patients with partial epilepsy, we focused on the prognostic value of any structural brain abnormality and of the location of the epileptogenic region.

Methods: A total of 2,200 adult outpatients were included in a hospital-based observational survey, with a follow-up of 1 to 7 years. Twenty-two percent of the patients exhibited generalized epilepsy, 62% partial epilepsy, and 16% undetermined epilepsy.

Results: Seizure control (>1 year without seizure) was achieved in 82% of patients who had idiopathic generalized epilepsy, 35% of those with symptomatic partial epilepsy, 45% of those with cryptogenic partial epilepsy, and 11% of those with partial epilepsy associated with hippocampal sclerosis (HS). Temporal lobe epilepsy (TLE) was the most refractory partial epilepsy, with only 20% of such patients remaining seizure free, compared with 36% of extra-TLE patients. In partial epilepsy, HS, cerebral dysgenesis, and dual pathology (HS and another lesion) were associated with a low rate of seizure-free patients (11%, 24%, and 3%, respectively). No significant difference in seizure control was found between patients with extra-TLE and those with TLE and no HS.

Conclusions: In adults, partial epilepsy is more difficult to treat than idiopathic generalized epilepsy. In patients who have partial epilepsy, the location of the epileptogenic zone does not seem to be a determining factor. Brain abnormalities-especially HS, either alone or associated with another lesion-are a major prognostic factor.

Received December 3, 1997. Accepted in final form July 2, 1998.




This article has been cited by other articles:


Home page
 Arch NeurolHome page
Y. Schiller
Seizure Relapse and Development of Drug Resistance Following Long-term Seizure Remission
Arch Neurol, October 1, 2009; 66(10): 1233 - 1239.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
R. D'Ambrosio, S. Hakimian, T. Stewart, D. R. Verley, J. S. Fender, C. L. Eastman, A. H. Sheerin, P. Gupta, R. Diaz-Arrastia, J. Ojemann, et al.
Functional definition of seizure provides new insight into post-traumatic epileptogenesis
Brain, October 1, 2009; 132(10): 2805 - 2821.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
B M Soeder, U Gleissner, H Urbach, H Clusmann, C E Elger, A Vincent, and C G Bien
Causes, presentation and outcome of lesional adult onset mediotemporal lobe epilepsy
J. Neurol. Neurosurg. Psychiatry, August 1, 2009; 80(8): 894 - 899.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
M. Yogarajah, N. K. Focke, S. Bonelli, M. Cercignani, J. Acheson, G. J. M. Parker, D. C. Alexander, A. W. McEvoy, M. R. Symms, M. J. Koepp, et al.
Defining Meyer's loop-temporal lobe resections, visual field deficits and diffusion tensor tractography
Brain, June 1, 2009; 132(6): 1656 - 1668.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
H. Choi, R. L. Sell, L. Lenert, P. Muennig, R. R. Goodman, F. G. Gilliam, and J. B. Wong
Epilepsy Surgery for Pharmacoresistant Temporal Lobe Epilepsy: A Decision Analysis
JAMA, December 3, 2008; 300(21): 2497 - 2505.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
J. Engel Jr
Surgical Treatment for Epilepsy: Too Little, Too Late?
JAMA, December 3, 2008; 300(21): 2548 - 2550.
[Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
S P Liimatainen, J A Raitanen, A M Ylinen, M A Peltola, and J T Peltola
The benefit of active drug trials is dependent on aetiology in refractory focal epilepsy
J. Neurol. Neurosurg. Psychiatry, July 1, 2008; 79(7): 808 - 812.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
G Kuchukhidze, I Unterberger, J Dobesberger, N Embacher, G Walser, E Haberlandt, T Gotwald, H Maier, M Ortler, S Felber, et al.
Electroclinical and imaging findings in ulegyria and epilepsy: a study on 25 patients
J. Neurol. Neurosurg. Psychiatry, May 1, 2008; 79(5): 547 - 552.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
Y. Schiller and Y. Najjar
Quantifying the response to antiepileptic drugs: Effect of past treatment history
Neurology, January 1, 2008; 70(1): 54 - 65.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
I. Kharatishvili, R. Immonen, O. Grohn, and A. Pitkanen
Quantitative diffusion MRI of hippocampus as a surrogate marker for post-traumatic epileptogenesis
Brain, December 1, 2007; 130(12): 3155 - 3168.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. Huberfeld, L. Wittner, S. Clemenceau, M. Baulac, K. Kaila, R. Miles, and C. Rivera
Perturbed Chloride Homeostasis and GABAergic Signaling in Human Temporal Lobe Epilepsy
J. Neurosci., September 12, 2007; 27(37): 9866 - 9873.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
W. D. Gaillard, S. Weinstein, J. Conry, P. L. Pearl, S. Fazilat, S. Fazilat, L. G. Vezina, P. Reeves-Tyer, and W. H. Theodore
Prognosis of children with partial epilepsy: MRI and serial 18FDG-PET
Neurology, February 27, 2007; 68(9): 655 - 659.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
C. G. Spooner, S. F. Berkovic, L. A. Mitchell, J. A. Wrennall, and A. S. Harvey
New-onset temporal lobe epilepsy in children: Lesion on MRI predicts poor seizure outcome
Neurology, December 26, 2006; 67(12): 2147 - 2153.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
P. Ryvlin, A. Montavont, and N. Nighoghossian
Optimizing therapy of seizures in stroke patients
Neurology, December 26, 2006; 67(12_suppl_4): S3 - S9.
[Abstract] [Full Text]

Home page
 BrainHome page
K. Jandova, D. Pasler, L. L. Antonio, C. Raue, S. Ji, M. Njunting, O. Kann, R. Kovacs, H.-J. Meencke, E. A. Cavalheiro, et al.
Carbamazepine-resistance in the epileptic dentate gyrus of human hippocampal slices
Brain, December 1, 2006; 129(12): 3290 - 3306.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
M. Pondal-Sordo, D. Diosy, J. F. Tellez-Zenteno, J. P. Girvin, and S. Wiebe
Epilepsy surgery involving the sensory-motor cortex
Brain, December 1, 2006; 129(12): 3307 - 3314.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
A. T. Berg and J. Engel Jr
Hippocampal atrophy and the prognosis of epilepsy: Some answers, more questions.
Neurology, July 11, 2006; 67(1): 12 - 13.
[Full Text] [PDF]

Home page
 NeurologyHome page
T.A.M. Cardoso, A. C. Coan, E. Kobayashi, C. A.M. Guerreiro, L. M. Li, and F. Cendes
Hippocampal abnormalities and seizure recurrence after antiepileptic drug withdrawal.
Neurology, July 11, 2006; 67(1): 134 - 136.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
S. Fauser, H.-J. Huppertz, T. Bast, K. Strobl, G. Pantazis, D.-M. Altenmueller, B. Feil, S. Rona, C. Kurth, D. Rating, et al.
Clinical characteristics in focal cortical dysplasia: a retrospective evaluation in a series of 120 patients
Brain, July 1, 2006; 129(7): 1907 - 1916.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
J Janszky, M Hoppe, F Behne, I Tuxhorn, H W Pannek, and A Ebner
Vagus nerve stimulation: predictors of seizure freedom
J. Neurol. Neurosurg. Psychiatry, March 1, 2005; 76(3): 384 - 389.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
J. Janszky, I. Janszky, R. Schulz, M. Hoppe, F. Behne, H. W. Pannek, and A. Ebner
Temporal lobe epilepsy with hippocampal sclerosis: predictors for long-term surgical outcome
Brain, February 1, 2005; 128(2): 395 - 404.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
S. M. Sisodiya
Surgery for focal cortical dysplasia
Brain, November 1, 2004; 127(11): 2383 - 2384.
[Full Text] [PDF]

Home page
 BrainHome page
S. Fauser, A. Schulze-Bonhage, J. Honegger, H. Carmona, H.-J. Huppertz, G. Pantazis, S. Rona, T. Bast, K. Strobl, B. J. Steinhoff, et al.
Focal cortical dysplasias: surgical outcome in 67 patients in relation to histological subtypes and dual pathology
Brain, November 1, 2004; 127(11): 2406 - 2418.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
P Kwan and J W Sander
The natural history of epilepsy: an epidemiological view
J. Neurol. Neurosurg. Psychiatry, October 1, 2004; 75(10): 1376 - 1381.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
O. Camilo and L. B. Goldstein
Seizures and Epilepsy After Ischemic Stroke
Stroke, July 1, 2004; 35(7): 1769 - 1775.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
F. Chassoux, F. Semah, V. Bouilleret, E. Landre, B. Devaux, B. Turak, F. Nataf, and F.-X. Roux
Metabolic changes and electro-clinical patterns in mesio-temporal lobe epilepsy: a correlative study
Brain, January 1, 2004; 127(1): 164 - 174.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
R. Diaz-Arrastia, Y. Gong, S. Fair, K. D. Scott, M. C. Garcia, M. C. Carlile, M. A. Agostini, and P. C. Van Ness
Increased Risk of Late Posttraumatic Seizures Associated With Inheritance of APOE{epsilon}4 Allele
Arch Neurol, June 1, 2003; 60(6): 818 - 822.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
C. Lamy, V. Domigo, F. Semah, C. Arquizan, D. Trystram, J. Coste, and J.L. Mas
Early and late seizures after cryptogenic ischemic stroke in young adults
Neurology, February 11, 2003; 60(3): 400 - 404.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
E. Kobayashi, M.D. D'Agostino, I. Lopes-Cendes, S.F. Berkovic, M.L. Li, E. Andermann, F. Andermann, and F. Cendes
Hippocampal atrophy and T2-weighted signal changes in familial mesial temporal lobe epilepsy
Neurology, February 11, 2003; 60(3): 405 - 409.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
R. Kumar, R. K. Gupta, M. Husain, D. K. Vatsal, S. Chawla, R. K. S. Rathore, and S. Pradhan
Magnetization Transfer MR Imaging in Patients with Posttraumatic Epilepsy
AJNR Am. J. Neuroradiol., February 1, 2003; 24(2): 218 - 224.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
J von Oertzen, H Urbach, S Jungbluth, M Kurthen, M Reuber, G Fernandez, and C E Elger
Standard magnetic resonance imaging is inadequate for patients with refractory focal epilepsy
J. Neurol. Neurosurg. Psychiatry, December 1, 2002; 73(6): 643 - 647.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
L Jutila, A Immonen, E Mervaala, J Partanen, K Partanen, M Puranen, R Kalviainen, I Alafuzoff, H Hurskainen, M Vapalahti, et al.
Long term outcome of temporal lobe epilepsy surgery: analyses of 140 consecutive patients
J. Neurol. Neurosurg. Psychiatry, November 1, 2002; 73(5): 486 - 494.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
L. Tassi, N. Colombo, R. Garbelli, S. Francione, G. Lo Russo, R. Mai, F. Cardinale, M. Cossu, A. Ferrario, C. Galli, et al.
Focal cortical dysplasia: neuropathological subtypes, EEG, neuroimaging and surgical outcome
Brain, August 1, 2002; 125(8): 1719 - 1732.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
R. Diaz-Arrastia, M. A. Agostini, and P. C. Van Ness
Evolving Treatment Strategies for Epilepsy
JAMA, June 12, 2002; 287(22): 2917 - 2920.
[Full Text] [PDF]

Home page
 J Child NeurolHome page
P. Pandley, J. Shah, C. Juhasz, Z. Pfund, and H. T. Chugani
Spontaneous Long-Term Remission of Intractable Partial Epilepsy in Childhood
J Child Neurol, June 1, 2002; 17(6): 466 - 470.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
F. Semah, C. Lamy, S. Demeret, and D. J. Dlugos
Hippocampal Sclerosis and Other Hippocampal Abnormalities in the Early Identification of Candidates for Epilepsy Surgery
Arch Neurol, June 1, 2002; 59(6): 1042 - 1043.
[Full Text] [PDF]

Home page
 BrainHome page
V. Navarro, J. Martinerie, M. L. V. Quyen, S. Clemenceau, C. Adam, M. Baulac, and F. Varela
Seizure anticipation in human neocortical partial epilepsy
Brain, March 1, 2002; 125(3): 640 - 655.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
S. M. Sisodiya, W.-R. Lin, B. N. Harding, M. V. Squier, and M. Thom
Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy
Brain, January 1, 2002; 125(1): 22 - 31.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
D. J. Dlugos
The Early Identification of Candidates for Epilepsy Surgery
Arch Neurol, October 1, 2001; 58(10): 1543 - 1546.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
S. Wiebe, W. T. Blume, J. P. Girvin, M. Eliasziw, and the Effectiveness and Efficiency of Surgery for Te
A Randomized, Controlled Trial of Surgery for Temporal-Lobe Epilepsy
N. Engl. J. Med., August 2, 2001; 345(5): 311 - 318.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
J. Engel Jr.
Mesial Temporal Lobe Epilepsy: What Have We Learned?
Neuroscientist, August 1, 2001; 7(4): 340 - 352.
[Abstract] [PDF]

Home page
 NeurologyHome page
S. R. Benbadis, W. O. Tatum, and a. F. L. Vale
When drugs don't work: An algorithmic approach to medically intractable epilepsy
Neurology, December 26, 2000; 55(12): 1780 - 1784.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
R. Diaz-Arrastia, M. A. Agostini, A. B. Frol, B. Mickey, J. Fleckenstein, E. Bigio, and P. C. Van Ness
Neurophysiologic and Neuroradiologic Features of Intractable Epilepsy After Traumatic Brain Injury in Adults
Arch Neurol, November 1, 2000; 57(11): 1611 - 1616.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
F. Loup, H.-G. Wieser, Y. Yonekawa, A. Aguzzi, and J.-M. Fritschy
Selective Alterations in GABAA Receptor Subtypes in Human Temporal Lobe Epilepsy
J. Neurosci., July 15, 2000; 20(14): 5401 - 5419.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
S. M. Sisodiya
Surgery for malformations of cortical development causing epilepsy
Brain, June 1, 2000; 123(6): 1075 - 1091.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
F. Picard, S. Baulac, P. Kahane, E. Hirsch, R. Sebastianelli, P. Thomas, F. Vigevano, P. Genton, R. Guerrini, C. A. Gericke, et al.
Dominant partial epilepsies: A clinical, electrophysiological and genetic study of 19 European families
Brain, June 1, 2000; 123(6): 1247 - 1262.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
P. Kwan and M. J. Brodie
Early Identification of Refractory Epilepsy
N. Engl. J. Med., February 3, 2000; 342(5): 314 - 319.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
J. Engel Jr
The Timing of Surgical Intervention for Mesial Temporal Lobe Epilepsy: A Plan for a Randomized Clinical Trial
Arch Neurol, November 1, 1999; 56(11): 1338 - 1341.
[Full Text] [PDF]

Home page
 NeurologyHome page
S. R. Benbadis and F. Semah
Is the underlying cause of epilepsy a major prognostic factor for recurrence?
Neurology, July 1, 1999; 53(2): 437 - 437.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1998 by AAN Enterprises, Inc.