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NEUROLOGY 1998;51:1502-1504
© 1998 American Academy of Neurology

Amygdala atrophy and seizure outcome after temporal lobe epilepsy surgery

S. S. Ho, MD, FRACP, MRCP, D. Consalvo, MD, F. Gilliam, MD, E. Faught, MD, E. Bilir, MD, R. Morawetz, MD and R. I. Kuzniecky, MD

From the Departments of Neurology (Drs. Ho, Kuzniecky, Consalvo, Gilliam, Faught, and Bilir) and Neurosurgery (Dr. Morawetz), UAB Epilepsy Center, University of Alabama at Birmingham, AL.

Address correspondence and reprint requests to Dr. Ruben I. Kuzniecky, Department of Neurology, UAB Station, Birmingham, AL 35294-0021.

Surgical outcome in hippocampal atrophy (n = 44) and amygdalohippocampal atrophy (n = 14) were compared. Hippocampal atrophy had better seizure-free outcome than amygdalohippocampal atrophy (80% versus 50%, p = 0.043). Severity of hippocampal atrophy correlated with duration of epilepsy in patients with hippocampal atrophy (r = 0.4, p = 0.007), but not in those with amygdalohippocampal atrophy, suggesting that these two groups may have a different pathogenesis.


Received February 2, 1998. Accepted in final form July 2, 1998.




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