| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Division of Neurology, Department of Medicine (Drs. Kothare, VanLandingham, and Radtke), and Division of Neurosurgery, Department of Surgery (Dr. Friedman), Duke University Medical Center, Durham, NC; Department of Neurology (Dr. Armon), Loma Linda University School of Medicine, Loma Linda, CA; and SW Texas Methodist Hospital Comprehensive Epilepsy Center (Dr. Luther), San Antonio, TX.
Address correspondence and reprint requests to Dr. Rodney A. Radtke, Division of Neurology, Department of Medicine, Box 3678, Duke University Medical Center, Durham, NC 27710.
The association between gray matter heterotopias and seizures is well established; whether seizures originate from these lesions is not known. We evaluated three patients with intractable complex partial seizures and periventricular nodular heterotopias (PNHs) with video-EEG monitoring with multiple depth electrodes, including placement in the PNH, to determine whether seizures originate from the PNH. In two of the three patients, all seizures arose from the PNH as low-voltage beta activity. In the third patient, 80% arose from the hippocampi and 20% from the heterotopia. PNHs may serve as an epileptogenic focus in patients with intractable epilepsy.
Presented in part at the 50th annual meeting of the American Academy of Neurology, Minneapolis, MN, April 1998.
Received April 3, 1998. Accepted in final form August 15, 1998.
This article has been cited by other articles:
|
|
 |
|
  J. Jacobs, P. LeVan, C.-E. Chatillon, A. Olivier, F. Dubeau, and J. Gotman High frequency oscillations in intracranial EEGs mark epileptogenicity rather than lesion type Brain, April 1, 2009; 132(4): 1022 - 1037. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Tyvaert, C. Hawco, E. Kobayashi, P. LeVan, F. Dubeau, and J. Gotman Different structures involved during ictal and interictal epileptic activity in malformations of cortical development: an EEG-fMRI study Brain, August 1, 2008; 131(8): 2042 - 2060. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Kobayashi, C. S. Hawco, C. Grova, F. Dubeau, and J. Gotman Widespread and intense BOLD changes during brief focal electrographic seizures Neurology, April 11, 2006; 66(7): 1049 - 1055. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Kobayashi, A. P. Bagshaw, C. Grova, J. Gotman, and F. Dubeau Grey matter heterotopia: what EEG-fMRI can tell us about epileptogenicity of neuronal migration disorders Brain, February 1, 2006; 129(2): 366 - 374. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Scherer, S. Schuele, L. Minotti, S. Chabardes, D. Hoffmann, and P. Kahane Intrinsic epileptogenicity of an isolated periventricular nodular heterotopia Neurology, August 9, 2005; 65(3): 495 - 496. [Full Text] [PDF]
|
|
|
|
 |
|
 R. Guerrini and T. Filippi Topical Review: Neuronal Migration Disorders, Genetics, and Epileptogenesis J Child Neurol, April 1, 2005; 20(4): 287 - 299. [Abstract] [PDF]
|
|
|
|
|
|
G. Battaglia, S. Franceschetti, L. Chiapparini, E. Freri, S. Bassanini, A. Giavazzi, A. Finardi, F. Taroni, and T. Granata Electroencephalographic Recordings of Focal Seizures in Patients Affected by Periventricular Nodular Heterotopia: Role of the Heterotopic Nodules in the Genesis of Epileptic Discharges J Child Neurol, April 1, 2005; 20(4): 369 - 377. [Abstract] [PDF]
|
|
|
|
|
|
S. U. Schuele and H. O. Luders Functional imaging in PNH caused by a new FilaminA mutation Neurology, March 22, 2005; 64(6): 1101 - 1102. [Full Text] [PDF]
|
|
|
|
|
|
Y. Aghakhani, D. Kinay, J. Gotman, L. Soualmi, F. Andermann, A. Olivier, and F. Dubeau The role of periventricular nodular heterotopia in epileptogenesis Brain, March 1, 2005; 128(3): 641 - 651. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Tassi, N. Colombo, M. Cossu, R. Mai, S. Francione, G. Lo Russo, C. Galli, M. Bramerio, G. Battaglia, R. Garbelli, et al. Electroclinical, MRI and neuropathological study of 10 patients with nodular heterotopia, with surgical outcomes Brain, February 1, 2005; 128(2): 321 - 337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Foldvary-Schaefer, J. Bautista, F. Andermann, G. Cascino, and S. Spencer Focal malformations of cortical development Neurology, March 23, 2004; 62(6_suppl_3): S14 - S19. [Full Text]
|
|
|
|
|
|
R. Guerrini and T. Filippi Topical Review: Neuronal Migration Disorders, Genetics, and Epileptogenesis J Child Neurol, March 1, 2004; 19(3): 287 - 299. [Abstract] [PDF]
|
|
|
|
|
|
G. Battaglia, S. Franceschetti, L. Chiapparini, E. Freri, S. Bassanini, A. Giavazzi, A. Finardi, F. Taroni, and T. Granata Electroencephalographic Recordings of Focal Seizures in Patients Affected by Periventricular Nodular Heterotopia: Role of the Heterotopic Nodules in the Genesis of Epileptic Discharges J Child Neurol, March 1, 2004; 19(3): 369 - 377. [Abstract] [PDF]
|
|
|
|
 |
|
 G. Battaglia, S. Pagliardini, L. Saglietti, F. Cattabeni, M. Di Luca, S. Bassanini, and V. Setola Neurogenesis in Cerebral Heterotopia Induced in Rats by Prenatal Methylazoxymethanol Treatment Cereb Cortex, July 1, 2003; 13(7): 736 - 748. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Spalice, G. Taddeucci, F. M. Perla, M. P. Pascali, and P. Iannetti Periventricular Nodular Heterotopia: Report of a Pediatric Series J Child Neurol, April 1, 2002; 17(4): 300 - 304. [Abstract] [PDF]
|
|
|
|
|
|
A. James Barkovich and R. I. Kuzniecky Gray matter heterotopia Neurology, December 12, 2000; 55(11): 1603 - 1608. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Borgatti, C. Zucca, P. Piccinelli, H. Fondazione Macchi, L. Radice, A. Tofani, R. Benti, and F. Triulzi Unilateral Periventricular Nodular Heterotopia Associated With Diffuse Areas of Cerebral Functional Abnormalities J Child Neurol, September 1, 2000; 15(9): 622 - 626. [Abstract] [PDF]
|
|
|
|
|
|
S. M. Sisodiya Surgery for malformations of cortical development causing epilepsy Brain, June 1, 2000; 123(6): 1075 - 1091. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Asano, D. C. Chugani, O. Muzik, C. Shen, C. Juhasz, J. Janisse, J. Ager, A. Canady, J. R. Shah, A. K. Shah, et al. Multimodality imaging for improved detection of epileptogenic foci in tuberous sclerosis complex Neurology, May 23, 2000; 54(10): 1976 - 1984. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Barkovich Morphologic Characteristics of Subcortical Heterotopia: MR Imaging Study AJNR Am. J. Neuroradiol., February 1, 2000; 21(2): 290 - 295. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
