Neurology 1999;52:170
© 1999 American Academy of Neurology
Brief Communications
Linkage of proximal myotonic myopathy to chromosome 3q
K. Ricker, MD,
T. Grimm, MD,
M. C. Koch, MD,
C. Schneider, MD,
W. Kress, MD, PhD,
C. D. Reimers, MD,
W. Schulte-Mattler, MD,
B. Mueller-Myhsok, MD,
K. V. Toyka, MD and
C. R. Mueller, PhD
From the Departments of Neurology (Drs. Ricker, Schneider, and Toyka) and Human Genetics (Drs. Grimm, Kress, and Mueller), University of Würzburg; Department of Human Genetics (Dr. Koch), University of Marburg; Department of Clinical Neurophysiology (Dr. Reimers), University of Göttingen; Department of Neurology (Dr. Schulte-Mattler), University of Halle; Bernhard Nocht Institute for Tropical Medicine (Dr. Mueller-Myhsok), Hamburg, Germany.
Address correspondence and reprint requests to Dr. Kenneth Ricker, An der Lehmgrube 9, D-97234 Reichenberg, Germany; e-mail: Kenneth.Ricker{at}t-online.de
We performed genetic linkage analysis in nine German proximal myotonic myopathy (PROMM) families using DNA-markers D3S1541 and D3S1589 from the region of the recently discovered gene locus of myotonic dystrophy type 2 (DM2) on chromosome 3q. Two-point analysis supplied an lod score of 5.9. We conclude that a gene causing PROMM is located on chromosome 3q. PROMM and DM2 may be allelic disorders or may be caused by closely linked genes.
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