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Linkage of proximal myotonic myopathy to chromosome 3q

From the Departments of Neurology (Drs. Ricker, Schneider, and Toyka) and Human Genetics (Drs. Grimm, Kress, and Mueller), University of Würzburg; Department of Human Genetics (Dr. Koch), University of Marburg; Department of Clinical Neurophysiology (Dr. Reimers), University of Göttingen; Department of Neurology (Dr. Schulte-Mattler), University of Halle; Bernhard Nocht Institute for Tropical Medicine (Dr. Mueller-Myhsok), Hamburg, Germany.

Address correspondence and reprint requests to Dr. Kenneth Ricker, An der Lehmgrube 9, D-97234 Reichenberg, Germany; e-mail: Kenneth.Ricker{at}t-online.de

We performed genetic linkage analysis in nine German proximal myotonic myopathy (PROMM) families using DNA-markers D3S1541 and D3S1589 from the region of the recently discovered gene locus of myotonic dystrophy type 2 (DM2) on chromosome 3q. Two-point analysis supplied an lod score of 5.9. We conclude that a gene causing PROMM is located on chromosome 3q. PROMM and DM2 may be allelic disorders or may be caused by closely linked genes.

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