| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the IRCCS San Giovanni di Dio–FBF (Drs. Frisoni, Geroldi, Bianchetti, and Trabucchi), Brescia, Italy; the Departments of Neurology (Drs. Laakso and Soininen) and Clinical Radiology (Dr. Laakso), Kuopio University Hospital, Kuopio, Finland; and the Institute of Radiology (Dr. Beltramello), University of Verona, Ospedale Borgo Roma, Verona, Italy.
Address correspondence and reprint requests to Dr. Giovanni B. Frisoni, Alzhiemer’s Unit, IRCCS San Giovanni di Dio, FBF, via Pilastroni 4, I-25123 Brescia, Italy; e-mail: frisoni{at}master.cci.unibs.it
OBJECTIVE: To describe atrophic changes of the hippocampus and entorhinal cortex in frontotemporal dementia (FTD) and compare them with those of AD.
BACKGROUND: The medial temporal lobe shows atrophic changes early in the course of AD, but whether these changes are specific to AD or occur in other degenerative dementias, and to what extent, is unclear.
METHODS: The authors measured the volumes of the left and right hippocampus and entorhinal cortex from MR images (1.5 T, 2-mm–thick slices) in 12 patients with FTD, 30 with AD, and 30 elderly control subjects.
RESULTS: In FTD patients, the left and right hippocampus (16% and 21% tissue loss) and the entorhinal cortex (28% and 27% loss) were more atrophic than the control subjects. Atrophy of the hippocampus in FTD was less severe than in AD, but atrophy of the entorhinal cortex was equally severe. Greater hippocampal and entorhinal cortex atrophy was present in the most severe patients in both groups (as high as a 49% tissue loss). The sensitivity of the hippocampus and the entorhinal cortex to discriminate FTD patients from control subjects was low (49% and 52%, respectively; specificity set at 90%), whereas hippocampal volumes could better differentiate AD patients from control subjects (80% sensitivity).
CONCLUSIONS: At variance with AD, detectable in vivo atrophy of the hippocampus might not be an early event in FTD. Differential patterns of atrophy might help in the diagnostic process of the degenerative dementias.
This article has been cited by other articles:
|
|
 |
|
  M. Monif, C. A. Reid, K. L. Powell, M. L. Smart, and D. A. Williams The P2X7 Receptor Drives Microglial Activation and Proliferation: A Trophic Role for P2X7R Pore J. Neurosci., March 25, 2009; 29(12): 3781 - 3791. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Jalbert, L. A. Daiello, and K. L. Lapane Dementia of the Alzheimer Type Epidemiol. Rev., November 1, 2008; 30(1): 15 - 34. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Colliot, G. Chetelat, M. Chupin, B. Desgranges, B. Magnin, H. Benali, B. Dubois, L. Garnero, F. Eustache, and S. Lehericy Discrimination between Alzheimer Disease, Mild Cognitive Impairment, and Normal Aging by Using Automated Segmentation of the Hippocampus Radiology, July 1, 2008; 248(1): 194 - 201. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. S. Liang, T. Dunckley, T. G. Beach, A. Grover, D. Mastroeni, K. Ramsey, R. J. Caselli, W. A. Kukull, D. McKeel, J. C. Morris, et al. Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set Physiol Genomics, April 1, 2008; 33(2): 240 - 256. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A D Hutchinson and J L Mathias Neuropsychological deficits in frontotemporal dementia and Alzheimer's disease: a meta-analytic review J. Neurol. Neurosurg. Psychiatry, September 1, 2007; 78(9): 917 - 928. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. A. Cardenas, A. L. Boxer, L. L. Chao, M. L. Gorno-Tempini, B. L. Miller, M. W. Weiner, and C. Studholme Deformation-Based Morphometry Reveals Brain Atrophy in Frontotemporal Dementia Arch Neurol, June 1, 2007; 64(6): 873 - 877. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.-T. Du, N. Schuff, J. H. Kramer, H. J. Rosen, M. L. Gorno-Tempini, K. Rankin, B. L. Miller, and M. W. Weiner Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia Brain, April 1, 2007; 130(4): 1159 - 1166. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. S. Liang, T. Dunckley, T. G. Beach, A. Grover, D. Mastroeni, D. G. Walker, R. J. Caselli, W. A. Kukull, D. McKeel, J. C. Morris, et al. Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain Physiol Genomics, February 12, 2007; 28(3): 311 - 322. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. T. Du, G. H. Jahng, S. Hayasaka, J. H. Kramer, H. J. Rosen, M. L. Gorno-Tempini, K. P. Rankin, B. L. Miller, M. W. Weiner, and N. Schuff Hypoperfusion in frontotemporal dementia and Alzheimer disease by arterial spin labeling MRI. Neurology, October 10, 2006; 67(7): 1215 - 1220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Barnes, J. L. Whitwell, C. Frost, K. A. Josephs, M. Rossor, and N. C. Fox Measurements of the Amygdala and Hippocampus in Pathologically Confirmed Alzheimer Disease and Frontotemporal Lobar Degeneration. Arch Neurol, October 1, 2006; 63(10): 1434 - 1439. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Xie, J. X. Xiao, G. L. Gong, Y. F. Zang, Y. H. Wang, H. K. Wu, and X. X. Jiang Voxel-based detection of white matter abnormalities in mild Alzheimer disease Neurology, June 27, 2006; 66(12): 1845 - 1849. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L A van de Pol, A Hensel, W M van der Flier, P-J Visser, Y A L Pijnenburg, F Barkhof, H J. Gertz, and P Scheltens Hippocampal atrophy on MRI in frontotemporal lobar degeneration and Alzheimer's disease J. Neurol. Neurosurg. Psychiatry, April 1, 2006; 77(4): 439 - 442. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Likeman, V. M. Anderson, J. M. Stevens, A. D. Waldman, A. K. Godbolt, C. Frost, M. N. Rossor, and N. C. Fox Visual Assessment of Atrophy on Magnetic Resonance Imaging in the Diagnosis of Pathologically Confirmed Young-Onset Dementias Arch Neurol, September 1, 2005; 62(9): 1410 - 1415. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Easton, R.M. Ridley, H.F. Baker, and D. Gaffan Unilateral Lesions of the Cholinergic Basal Forebrain and Fornix in One Hemisphere and Inferior Temporal Cortex in the Opposite Hemisphere Produce Severe Learning Impairments in Rhesus Monkeys Cereb Cortex, July 1, 2002; 12(7): 729 - 736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. A. Thacker, A. R. Varma, D. Bathgate, S. Stivaros, J. S. Snowden, D. Neary, and A. Jackson Dementing Disorders: Volumetric Measurement of Cerebrospinal Fluid to Distinguish Normal from Pathologic Findings—Feasibility Study Radiology, July 1, 2002; 224(1): 278 - 285. [Abstract] [Full Text]
|
|
|
|
|
|
A. T. Du, N. Schuff, M. P. Laakso, X. P. Zhu, W. J. Jagust, K. Yaffe, J. H. Kramer, B. L. Miller, B. R. Reed, D. Norman, et al. Effects of subcortical ischemic vascular dementia and AD on entorhinal cortex and hippocampus Neurology, June 11, 2002; 58(11): 1635 - 1641. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M D Greicius, M D Geschwind, and B L Miller Presenile dementia syndromes: an update on taxonomy and diagnosis J. Neurol. Neurosurg. Psychiatry, June 1, 2002; 72(6): 691 - 700. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. D. Bigler, C. V. Andersob, and D. D. Blatter Temporal Lobe Morphology in Normal Aging and Traumatic Brain Injury AJNR Am. J. Neuroradiol., February 1, 2002; 23(2): 255 - 266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. B. Frisoni, C. Geroldi, A. Beltramello, A. Bianchetti, G. Binetti, G. Bordiga, C. DeCarli, M. P. Laakso, H. Soininen, C. Testa, et al. Radial Width of the Temporal Horn: A Sensitive Measure in Alzheimer Disease AJNR Am. J. Neuroradiol., January 1, 2002; 23(1): 35 - 47. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Chan, N. C. Fox, R. Jenkins, R. I. Scahill, W. R. Crum, and M. N. Rossor Rates of global and regional cerebral atrophy in AD and frontotemporal dementia Neurology, November 27, 2001; 57(10): 1756 - 1763. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A T Du, N Schuff, D Amend, M P Laakso, Y Y Hsu, W J Jagust, K Yaffe, J H Kramer, B Reed, D Norman, et al. Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer's disease J. Neurol. Neurosurg. Psychiatry, October 1, 2001; 71(4): 441 - 447. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-Y. Hsu, A.-T. Du, N. Schuff, and M. W. Weiner Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy in Dementias J Geriatr Psychiatry Neurol, September 1, 2001; 14(3): 145 - 166. [Abstract] [PDF]
|
|
|
|
|
|
C. J. Galton, K. Patterson, K. Graham, M.A. Lambon-Ralph, G. Williams, N. Antoun, B.J. Sahakian, and J.R. Hodges Differing patterns of temporal atrophy in Alzheimer's disease and semantic dementia Neurology, July 24, 2001; 57(2): 216 - 225. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G B FRISONI Structural imaging in the clinical diagnosis of Alzheimer's disease: problems and tools J. Neurol. Neurosurg. Psychiatry, June 1, 2001; 70(6): 711 - 718. [Full Text] [PDF]
|
|
|
|
|
|
C J Galton, B Gomez-Anson, N Antoun, P Scheltens, K Patterson, M Graves, B J Sahakian, and J R Hodges Temporal lobe rating scale: application to Alzheimer's disease and frontotemporal dementia J. Neurol. Neurosurg. Psychiatry, February 1, 2001; 70(2): 165 - 173. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-O. Wahlund, P. Julin, S.-E. Johansson, and P. Scheltens Visual rating and volumetry of the medial temporal lobe on magnetic resonance imaging in dementia: a comparative study J. Neurol. Neurosurg. Psychiatry, November 1, 2000; 69(5): 630 - 635. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. D. Bigler, C. M. Lowry, C. V. Anderson, S. C. Johnson, J. Terry, and M. Steed Dementia, Quantitative Neuroimaging, and Apolipoprotein E Genotype AJNR Am. J. Neuroradiol., November 1, 2000; 21(10): 1857 - 1868. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hanyu, T. Asano, T. Iwamoto, M. Takasaki, H. Shindo, and K. Abe Magnetization Transfer Measurements of the Hippocampus in Patients with Alzheimer's Disease, Vascular Dementia, and Other Types of Dementia AJNR Am. J. Neuroradiol., July 1, 2000; 21(7): 1235 - 1242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. E. Hogan, K. E. Mark, L. Wang, S. Joshi, M. I. Miller, and R. D. Bucholz Mesial Temporal Sclerosis and Temporal Lobe Epilepsy: MR Imaging Deformation-based Segmentation of the Hippocampus in Five Patients Radiology, July 1, 2000; 216(1): 291 - 297. [Abstract] [Full Text]
|
|
|
|
|
|
T. A. Ala, G. O. Beh, and W. H. Frey II Pure hippocampal sclerosis: A rare cause of dementia mimicking Alzheimer's disease Neurology, February 22, 2000; 54(4): 843 - 848. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Savolainen, M. P. Laakso, L. Paljärvi, I. Alafuzoff, H. Hurskainen, K. Partanen, H. Soininen, and M. Vapalahti MR Imaging of the Hippocampus in Normal Pressure Hydrocephalus: Correlations with Cortical Alzheimer's Disease Confirmed by Pathologic Analysis AJNR Am. J. Neuroradiol., February 1, 2000; 21(2): 409 - 414. [Abstract] [Full Text]
|
|
|
|
|
|
C Geroldi, M P Laakso, C DeCarli, A Beltramello, A Bianchetti, H Soininen, M Trabucchi, and G B Frisoni Apolipoprotein E genotype and hippocampal asymmetry in Alzheimer's disease: a volumetric MRI study J. Neurol. Neurosurg. Psychiatry, January 1, 2000; 68(1): 93 - 96. [Abstract] [Full Text]
|
|
|
|
|
|
C. Geroldi, M. Pihlajamaki, M. P. Laakso, C. DeCarli, A. Beltramello, A. Bianchetti, H. Soininen, M. Trabucchi, and G. B. Frisoni APOE-{epsilon}4 is associated with less frontal and more medial temporal lobe atrophy in AD Neurology, November 1, 1999; 53(8): 1825 - 1825. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
