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From The Saul R. Korey Department of Neurology (Drs. Buschke and Kuslansky, M. Katz, and Drs. Sliwinski, Eckholdt, and Lipton), Einstein Aging Study (Drs. Buschke and Kuslansky, M. Katz, and Drs. Sliwinski, Eckholdt, and Lipton), Rose F. Kennedy Center for Mental Retardation and Human Development (Drs. Buschke, Kuslansky, Sliwinski, and Eckholdt), and Department of Epidemiology and Social Medicine (Dr. Lipton), Albert Einstein College of Medicine, Bronx, NY; Department of Epidemiology (Dr. Stewart), School of Public Health, The Johns Hopkins University, Baltimore, MD; and Innovative Medical Research (Drs. Stewart and Lipton), Towson, MD.
Address correspondence and reprint requests to Dr. Herman Buschke, Department of Neurology, Kennedy 912, Albert Einstein College of Medicine, Bronx, NY 10461.
OBJECTIVES: To validate a sensitive and specific screening test for AD and other dementias, assess its reliability and discriminative validity, and present normative data for its use in various applied settings.
BACKGROUND: To improve discrimination in screening for AD and dementia, we developed the Memory Impairment Screen (MIS), a 4-minute, four-item, delayed free- and cued-recall test of memory impairment. The MIS uses controlled learning to ensure attention, induce specific semantic processing, and optimize encoding specificity to improve detection of dementia.
METHODS: Equivalent forms of the MIS were given at the beginning and end of the testing session to assess alternate forms reliability. Discriminative validity was assessed in a criterion sample of 483 aged individuals, 50 of whom had dementia according to Diagnostic and Statistical Manual of Mental Disorders (3rd ed., revised) criteria.
RESULTS: The MIS had good alternate forms reliability, high construct validity for memory impairment, and good discriminative validity in terms of sensitivity, specificity, and positive predictive value. We present normative data for use in settings with different base rates (prevalences) of AD and dementia.
CONCLUSION: The MIS provides efficient, reliable, and valid screening for AD and other dementias.
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