Neurology 1999;52:395
© 1999 American Academy of Neurology
Brief Communications
Mortality cancer risk in parkinsonian patients: A population-based study
Nicola Vanacore, MD,
Stefania Spila-Alegiani, MSc,
Roberto Raschetti, MSc and
Giuseppe Meco, MD
From the Department of Neurological Sciences (Drs. Vanacore and Meco), La Sapienza University; and the Department of Epidemiology and Biostatistics (S. Spila-Alegiani and R. Raschetti), Istituto Superiore di Sanità, Rome, Italy.
Address correspondence and reprint requests to Stefania Spila-Alegiani, Istituto Superiore di Sanità, Department of Epidemiology and Biostatistics, Viale Regina Elena, 299, 00161 Rome, Italy; e-mail: sspila{at}iss.it
Cancer mortality in a population-based cohort of 10,322 parkinsonian patients (448 deaths observed during 1987 to 1994) was compared with that of the Italian province of Rome using the standardized mortality ratio (SMR). The overall cancer mortality risk was lower in this cohort than in the reference population (SMR, 56; 95% CI, 51 to 61). This reduction included most cancer sites as well as both smoking-related (SMR, 51; 95% CI, 42 to 60) and nonsmoking-related cancers (SMR, 58; 95% CI, 52 to 65). The observed reduction in cancer mortality risk in this cohort cannot be explained entirely by the hypothesis that smokers are less likely to develop PD.
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