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Neurology 1999;52:398
© 1999 American Academy of Neurology
Brief Communications

Effects of antithrombin on Binswanger’s disease with antiphospholipid antibody syndrome

I. Akiguchi, MD, H. Tomimoto, MD, M. Kinoshita, MD, H. Wakita, MD, A. Osaki, MD, M. Nishimura, MD and J. Kimura, MD

From the Department of Neurology, Faculty of Medicine, Kyoto University, Japan.

Address correspondence and reprint requests to Dr. Ichiro Akiguchi, Department of Neurology, Faculty of Medicine, Kyoto University, 54 Shogoin-Kawaracho, Sakyo-ku, Kyoto 606-8507, Japan.

The authors present a family with Binswanger’s disease (BD) and antiphospholipid antibody syndrome (APAS). In one patient from this family, lupus anticoagulant and high levels of hemostatic markers were detected. The presence of BD and the clinicobiological improvements observed after antithrombin treatment in this patient are peculiar to this familial case of APAS.




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