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Neurology 1999;52:414
© 1999 American Academy of Neurology
Brief Communications

Bilateral optic neuropathy with IgG{kappa} multiple myeloma improved after myeloablative chemotherapy

F. S. Lieberman, MD, J. Odel, MD, J. Hirsh, PhD, M. Heinemann, MD, J. Michaeli, MD and J. Posner, MD

From the Departments of Neurology (Drs. Lieberman, Hirsh, and Posner), Ophthalmology (Dr. Heinemann), and Medicine (Dr. Michaeli), Memorial Sloan–Kettering Cancer Center and Cornell University Medical College; and the Department of Ophthalmology (Dr. Odel), Columbia Presbyterian Medical Center, New York, NY.

Address correspondence and reprint requests to Dr. Frank Lieberman, Department of Neurology, Box 1052, Mount Sinai Medical Center, One Gustave L. Levy Place, New York, NY 10029; e-mail: frank_lieberman{at}smtplink.mssm.edu

A 49-year-old woman with immunoglobulin G{kappa} multiple myeloma developed progressive visual loss with bilateral upper and lower central arcuate scotomas. Funduscopic and electrophysiologic studies indicated bilateral optic neuropathy. The immunoglobulin G fraction of the patient’s serum reacted with retinal ganglionic cells in bovine retina. The visual abnormalities remitted after myeloablative chemotherapy and disappearance of the paraprotein.




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