| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Service de Neurologie and Laboratoire Louis Ranvier (Drs. Bouchard, Planté, Adams, Guglielmi, and Said) and the Laboratoire de Neuropathologie (Dr. Lacroix), Hôpital de Bicêtre, Université Paris XI; and Service de Neurologie (Dr. Chedru), Hôpital de Meaux, France.
Address correspondence and reprint requests to Dr. Gérard Said, Service de Neurologie, Centre Hospitalier Universitaire de Bicêtre, 94275 Le Kremlin Bicêtre, France; e-mail: gerardsaid{at}netscape.net
OBJECTIVE: To evaluate the clinicopathologic features and prognostic factors of 100 patients with chronic inflammatory demyelinating polyneuropathy (CIDP).
METHODS: Comparison of clinical and biopsy findings with functional score evaluated an average of 6 years after referral.
RESULTS: CIDP followed a relapsing course in 14% of the patients and a progressive course in 45%. After progressive onset, little change was noted during follow-up in the others. Five patients had symptomatic involvement of the CNS. Teased fiber preparations of nerve biopsy specimens showed that 68 patients had purely demyelinative lesions, 20 had mixed axonal and demyelinative lesions, and 5 had predominantly axonal lesions. Axonal loss was a common finding, with 47% of the patients retaining less than half of the normal density of fibers. Inflammatory infiltrates, found in 18 samples, were prominent only in 4. Of the 83 patients evaluated an average of 6 years after onset, 56 were in good condition; 24 had deteriorated and failed to respond to treatment, including 9 patients who died as a consequence of their neurologic deficit. Progressive course, CNS involvement, high proportion of fibers showing active demyelination on nerve biopsy, and axonal loss overall correlated with higher disability.
CONCLUSION: Axonal loss is the major long-term pejorative prognostic factor in CIDP.
This article has been cited by other articles:
|
|
 |
|
  H Zephir, T Stojkovic, P Latour, A Lacour, J de Seze, O Outteryck, C-A Maurage, C Monpeurt, P Chatelet, E Ovelacq, et al. Relapsing demyelinating disease affecting both the central and peripheral nervous systems J. Neurol. Neurosurg. Psychiatry, September 1, 2008; 79(9): 1032 - 1039. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D. Weiss, J. C. Oakley, and G. D. Meekins Hypoglossal neuropathy in Lewis-Sumner syndrome masquerading as motor neuron disease. Neurology, July 11, 2006; 67(1): 175 - 176. [Full Text] [PDF]
|
|
|
|
|
|
S Kuwabara, S Misawa, M Mori, N Tamura, M Kubota, and T Hattori Long term prognosis of chronic inflammatory demyelinating polyneuropathy: a five year follow up of 38 cases J. Neurol. Neurosurg. Psychiatry, January 1, 2006; 77(1): 66 - 70. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Koller, B. C. Kieseier, S. Jander, and H.-P. Hartung Chronic Inflammatory Demyelinating Polyneuropathy N. Engl. J. Med., March 31, 2005; 352(13): 1343 - 1356. [Full Text] [PDF]
|
|
|
|
 |
|
 K. Viala, L. Renie, T. Maisonobe, A. Behin, J. Neil, J. M. Leger, and P. Bouche Follow-up study and response to treatment in 23 patients with Lewis-Sumner syndrome Brain, September 1, 2004; 127(9): 2010 - 2017. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Magda, N. Latov, T. H. Brannagan III, L. H. Weimer, R. L. Chin, and H. W. Sander Comparison of Electrodiagnostic Abnormalities and Criteria in a Cohort of Patients With Chronic Inflammatory Demyelinating Polyneuropathy Arch Neurol, December 1, 2003; 60(12): 1755 - 1759. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. W. Sander and N. Latov Research criteria for defining patients with CIDP Neurology, April 22, 2003; 60(90083): S8 - 15. [Abstract] [Full Text]
|
|
|
|
|
|
H. W. Sander and E. T. Hedley-Whyte Case 6-2003 - A Nine-Year-Old Girl with Progressive Weakness and Areflexia N. Engl. J. Med., February 20, 2003; 348(8): 735 - 743. [Full Text] [PDF]
|
|
|
|
|
|
N. Latov Diagnosis of CIDP Neurology, December 24, 2002; 59(90126): S2 - 6. [Abstract] [Full Text]
|
|
|
|
|
|
B. C. Kieseier, M. C. Dalakas, and H.-P. Hartung Immune mechanisms in chronic inflammatory demyelinating neuropathy Neurology, December 24, 2002; 59(90126): S7 - 12. [Abstract] [Full Text]
|
|
|
|
|
|
G. Said Indications and Usefulness of Nerve Biopsy Arch Neurol, October 1, 2002; 59(10): 1532 - 1535. [Full Text] [PDF]
|
|
|
|
|
|
S Kuwabara, K Ogawara, S Misawa, M Mori, and T Hattori Distribution patterns of demyelination correlate with clinical profiles in chronic inflammatory demyelinating polyneuropathy J. Neurol. Neurosurg. Psychiatry, January 1, 2002; 72(1): 37 - 42. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. M. J. Bosboom, L. H. van den Berg, H. Franssen, P. C. L. M. Giesbergen, H. Z. Flach, A. M. van Putten, H. Veldman, and J. H. J. Wokke Diagnostic value of sural nerve demyelination in chronic inflammatory demyelinating polyneuropathy Brain, December 1, 2001; 124(12): 2427 - 2438. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 What Is the Long-Term Prognosis for Patients with CIDP? Journal Watch Neurology, May 1, 1999; 1999(501): 14 - 14. [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
