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Neurology 1999;52:644
© 1999 American Academy of Neurology


Brief Communications

A tentative interpretation of electromyographic regional differences in bulbar- and limb-onset ALS

A. Cappellari, MD, A. Brioschi, MD, S. Barbieri, MD, M. Braga, MD, G. Scarlato, MD and V. Silani, MD

From the Institute of Neurology, "Dino Ferrari" Center (Drs. Cappellari, Barbieri, Braga, Scarlato, and Silani), University of Milan Medical School, IRCCS Maggiore Hospital, Milan; and the Department of Rehabilitation Medicine (Dr. Brioschi), IRCCS Istituto Auxologico Italiano, Verbania, Italy.

Address correspondence and reprint requests to Dr. Vincenzo Silani, Institute of Neurology, University of Milan Medical School, IRCCS Maggiore Hospital, Via Francesco Sforza 35, I-20122 Milan, Italy; e-mail: Vincenzo.Silani{at}venere.inet.it

Electromyography (EMG) could be useful in defining regional motor neuron vulnerability in ALS. We performed EMG in 36 sporadic ALS patients (9 with bulbar-onset and 27 with limb-onset symptoms). Active denervation was more frequent in limb than in corresponding paraspinal muscles, in the thoracic paraspinal, and in the bulbo-cervical muscles in patients with bulbar-onset symptoms. These results are consistent with a regional motor neuron vulnerability along with a nerve length-dependent liability.




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M. de Carvalho, C. Bentes, A. Cappellari, S. Barbieri, and V. Silani
A tentative interpretation of electromyographic regional differences in bulbar- and limb-onset ALS
Neurology, January 25, 2000; 54(2): 536 - 536.
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