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Neurology 1999;52:657
© 1999 American Academy of Neurology
Brief Communications

Progressive multifocal leukoencephalopathy: Unusual MRI findings and prolonged survival in a pregnant woman

Maria José Rosas, MD, Fernanda Simões-Ribeiro, MD, Shu F. An, MD, PhD and Nuno Sousa, MD

From the Departments of Neurology (Drs. Rosas and Simões-Ribeiro) and Neuroradiology (Dr. Sousa), Hospital S. João, Alameda Prof. Hernâni Monteiro, Porto, Portugal; and the Department of Neuropathology (Dr. An), Institute of Neurology, Queen Square, London, UK.

Address correspondence and reprint requests to Dr. M.J. Rosas, Department of Neurology, Hospital S. João, Alameda Prof. Hernâni Monteiro, 4200 Porto, Portugal; e-mail: nop03877{at}telepac.pt

We report a biopsy-proven case of progressive multifocal leukoencephalopathy (PML) in a pregnant woman without obvious underlying immune disorder. MRI showed lesion enhancement and deep gray matter involvement, which are uncommon imaging patterns in PML. The clinical course in this case is also rather atypical, as the patient is alive 16 months after disease onset. The combination of these unusual characteristics in PML is unknown and indicates that the criteria for this disease may need to be redefined.




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