Neurology®
The most widely read and highly cited peer-reviewed Neurology journal
Quick Search
Advanced Search
This Article
Right arrow Full Text
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Marder, K.
Right arrow Articles by Mayeux, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Marder, K.
Right arrow Articles by Mayeux, R.
Neurology 1999;52:719
© 1999 American Academy of Neurology
Articles

Risk of Alzheimer’s disease in relatives of Parkinson’s disease patients with and without dementia

K. Marder, MD, MPH, M.-X. Tang, PhD, B. Alfaro, MS, H. Mejia, MS, L. Cote, MD, E. Louis, MD, MSc, Y. Stern, PhD and R. Mayeux, MD, MSc

From the Gertrude H. Sergievsky Center (Drs. Marder, Tang, Alfaro, Mejia, Cote, Louis, Stern, and Mayeux) and the Departments of Neurology (Drs. Marder, Alfaro, Mejia, Cote, Louis, Stern, and Mayeux), and Psychiatry (Drs. Stern and Mayeux), College of Physicians and Surgeons; and the Divisions of Epidemiology and Biostatistics (Dr. Tang), School of Public Health at Columbia University (Dr. Mayeux), New York, NY.

Address correspondence and reprint requests to Dr. Karen Marder, G.H. Sergievsky Center, 630 West 168th Street, New York, NY 10032.

OBJECTIVE: To determine whether first-degree relatives of PD patients with dementia were at increased risk for the development of AD compared with first-degree relatives of nondemented PD patients and nondemented normal subjects from the community.

METHODS: A structured family history interview was administered to 146 nondemented PD patients, 120 patients with PD and dementia, and 903 normal subjects from the community to ascertain the presence of AD among parents and siblings of these subjects. Cox proportional hazards models with double censoring techniques for missing information were used to model the risk of AD among relatives.

RESULTS: No increase in risk of AD was found among parents of patients with PD and dementia or parents of nondemented PD patients compared with parents of normal subjects. However, siblings of demented PD patients were three times as likely (relative risk [RR] = 3.2, 95% confidence interval [CI] = 1.1 to 9.4, p < 0.04) as siblings of normal subjects to develop AD. When only siblings >65 years of age were considered, there was a fivefold increase in risk of AD among siblings of demented PD patients compared with siblings of normal subjects (RR = 4.9, 95% CI = 1.1 to 21.4, p < 0.03). The risk of AD was also increased for female relatives, regardless of whether the woman was a relative of a demented PD patient, a nondemented PD patient, or a normal subject. Ethnicity and APOE genotype did not affect dementia status among relatives.

CONCLUSIONS: The increased risk of AD in siblings of demented PD patients compared with siblings of normal subjects supports the possibility of familial aggregation of AD and PD with dementia.




This article has been cited by other articles:


Home page
 J Geriatr Psychiatry NeurolHome page
M. W. Kurz, G. Dekomien, O. B. Nilsen, J. P. Larsen, D. Aarsland, and G. Alves
APOE Alleles in Parkinson Disease and Their Relationship to Cognitive Decline: A Population-based, Longitudinal Study
J Geriatr Psychiatry Neurol, September 1, 2009; 22(3): 166 - 170.
[Abstract] [PDF]

Home page
 NeurologyHome page
L. D. Kaat, A.J.W. Boon, A. Azmani, W. Kamphorst, M. M.B. Breteler, B. Anar, P. Heutink, and J. C. van Swieten
Familial aggregation of parkinsonism in progressive supranuclear palsy
Neurology, July 14, 2009; 73(2): 98 - 105.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
W. A. Rocca, J. H. Bower, J. E. Ahlskog, A. Elbaz, B. R. Grossardt, S. K. McDonnell, D. J. Schaid, and D. M. Maraganore
Risk of Cognitive Impairment or Dementia in Relatives of Patients With Parkinson Disease
Arch Neurol, October 1, 2007; 64(10): 1458 - 1464.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
D. Paleacu, E. Schechtman, and R. Inzelberg
Association between family history of dementia and hallucinations in Parkinson disease
Neurology, May 24, 2005; 64(10): 1712 - 1715.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
W. Huang, C. Qiu, E. von Strauss, B. Winblad, and L. Fratiglioni
APOE Genotype, Family History of Dementia, and Alzheimer Disease Risk: A 6-Year Follow-up Study
Arch Neurol, December 1, 2004; 61(12): 1930 - 1934.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
G. Levy, E. D. Louis, H. Mejia-Santana, L. Cote, H. Andrews, J. Harris, C. Waters, B. Ford, S. Frucht, S. Fahn, et al.
Lack of Familial Aggregation of Parkinson Disease and Alzheimer Disease
Arch Neurol, July 1, 2004; 61(7): 1033 - 1039.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
H. Jacobs, P. Vieregge, K. Marder, M. Tang, E. Louis, and R. Mayeux
Risk of Alzheimer's disease in relatives of Parkinson's disease patients with and without dementia
Neurology, March 14, 2000; 54(5): 1208 - 1209.
[Full Text] [PDF]