Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Benson, R. R.
Right arrow Articles by Rosen, B. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Benson, R. R.
Right arrow Articles by Rosen, B. R.
Neurology 1999;52:798
© 1999 American Academy of Neurology
Articles

Language dominance determined by whole brain functional MRI in patients with brain lesions

R. R. Benson, MD, D. B. FitzGerald, BSEE, MBA, L. L. LeSueur, PhD, D. N. Kennedy, PhD, K. K. Kwong, PhD, B. R. Buchbinder, MD, T. L. Davis, PhD, R. M. Weisskoff, PhD, T. M. Talavage, PhD, W. J. Logan, MD, G. R. Cosgrove, MD, FRCS(C), J. W. Belliveau, PhD and B. R. Rosen, MD, PhD

From the Department of Neurology (Dr. Benson), University of Connecticut Health Center, Farmington, CT; MGH-NMR Center, Department of Radiology (D.B. FitzGerald and Drs. Kennedy, Kwong, Buchbinder, Weisskoff, Belliveau, and Rosen), Massachusetts General Hospital, Harvard Medical School, Boston, MA; Department of Neurology (Dr. Kennedy), Center for Morphometric Analysis, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Department of Electrical and Computer Engineering (Dr. Talavage), Purdue University; Division of Neurology (Dr. Logan), The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Neurosurgery (Dr. Cosgrove), Massachusetts General Hospital, Harvard Medical School, Charlestown, MA; Department of Neurology (Dr. LeSueur), Massachusetts General Hospital, Boston, MA; Mallinckrodt Institute of Radiology (Dr. Davis), Washington University Medical Center, St. Louis, MO; University of Massachusetts Medical School (Dr. FitzGerald), Worcester, MA.

Address correspondence and reprint requests to Dr. Randall R. Benson, University of Connecticut Health Center, Department of Neurology, 263 Farmington Avenue, Farmington, CT 06030-1845.

BACKGROUND: Functional MRI (fMRI) is of potential value in determining hemisphere dominance for language in epileptic patients.

OBJECTIVE: To develop and validate an fMRI-based method of determining language dominance for patients with a wide range of potentially operable brain lesions in addition to epilepsy.

METHODS: Initially, a within-subjects design was used with 19 healthy volunteers (11 strongly right-handed, 8 left-handed) to determine the relative lateralizing usefulness of three different language tasks in fMRI. An automated, hemispheric analysis of laterality was used to analyze whole brain fMRI data sets. To evaluate the clinical usefulness of this method, we compared fMRI-determined laterality with laterality determined by Wada testing or electrocortical stimulation mapping, or both, in 23 consecutive patients undergoing presurgical evaluation of language dominance.

RESULTS: Only the verb generation task was reliably lateralizing. fMRI, using the verb generation task and an automated hemispheric analysis method, was concordant with invasive measures in 22 of 23 patients (12 Wada, 11 cortical stimulation). For the single patient who was discordant, in whom a tumor involved one-third of the left hemisphere, fMRI became concordant when the tumor and its reflection in the right hemisphere were excluded from laterality analysis. No significant negative correlation was obtained between lesion size and strength of laterality for the patients with lesions involving the dominant hemisphere.

CONCLUSION: This fMRI method shows potential for evaluating language dominance in patients with a variety of brain lesions.




This article has been cited by other articles:


Home page
 Am. J. Neuroradiol.Home page
I.M. Ruff, N.M. Petrovich Brennan, K.K. Peck, B.L. Hou, V. Tabar, C.W. Brennan, and A.I. Holodny
Assessment of the Language Laterality Index in Patients with Brain Tumor Using Functional MR Imaging: Effects of Thresholding, Task Selection, and Prior Surgery
AJNR Am. J. Neuroradiol., March 1, 2008; 29(3): 528 - 535.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
L. S. Medina, B. Bernal, and J. Ruiz
Role of Functional MR in Determining Language Dominance in Epilepsy and Nonepilepsy Populations: A Bayesian Analysis
Radiology, January 1, 2007; 242(1): 94 - 100.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
W. Yuan, S. K. Holland, K. M. Cecil, K. N. Dietrich, S. D. Wessel, M. Altaye, R. W. Hornung, M. D. Ris, J. C. Egelhoff, and B. P. Lanphear
The Impact of Early Childhood Lead Exposure on Brain Organization: A Functional Magnetic Resonance Imaging Study of Language Function
Pediatrics, September 1, 2006; 118(3): 971 - 977.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
G.S. Harrington, M.H. Buonocore, and S. T. Farias
Intrasubject reproducibility of functional MR imaging activation in language tasks.
AJNR Am. J. Neuroradiol., April 1, 2006; 27(4): 938 - 944.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
M. P. Richardson, B. A. Strange, J. S. Duncan, and R. J. Dolan
Memory fMRI in left hippocampal sclerosis: Optimizing the approach to predicting postsurgical memory
Neurology, March 14, 2006; 66(5): 699 - 705.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
M. M. Berl, L. M. Balsamo, B. Xu, E. N. Moore, S. L. Weinstein, J. A. Conry, P. L. Pearl, B. C. Sachs, C. B. Grandin, C. Frattali, et al.
Seizure focus affects regional language networks assessed by fMRI
Neurology, November 22, 2005; 65(10): 1604 - 1611.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
M. Kocak, J. L. Ulmer, B. B. Biswal, A. Aralasmak, D. L. Daniels, and L. P. Mark
The Influence of Gender on Auditory and Language Cortical Activation Patterns: Preliminary Data
AJNR Am. J. Neuroradiol., October 1, 2005; 26(9): 2248 - 2255.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
L. S. Medina, B. Bernal, C. Dunoyer, L. Cervantes, M. Rodriguez, E. Pacheco, P. Jayakar, G. Morrison, J. Ragheb, and N. R. Altman
Seizure Disorders: Functional MR Imaging for Diagnostic Evaluation and Surgical Treatment--Prospective Study
Radiology, July 1, 2005; 236(1): 247 - 253.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
E. Pataraia, P. G. Simos, E. M. Castillo, R. L. Billingsley-Marshall, A. L. McGregor, J. I. Breier, S. Sarkari, and A. C. Papanicolaou
Reorganization of language-specific cortex in patients with lesions or mesial temporal epilepsy
Neurology, November 23, 2004; 63(10): 1825 - 1832.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
M. P. Richardson, B. A. Strange, P. J. Thompson, S. A. Baxendale, J. S. Duncan, and R. J. Dolan
Pre-operative verbal memory fMRI predicts post-operative memory decline after left temporal lobe resection
Brain, November 1, 2004; 127(11): 2419 - 2426.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
W. D. Gaillard, L. Balsamo, B. Xu, C. McKinney, P. H. Papero, S. Weinstein, J. Conry, P. L. Pearl, B. Sachs, S. Sato, et al.
fMRI language task panel improves determination of language dominance
Neurology, October 26, 2004; 63(8): 1403 - 1408.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
A. G. Wood, A. S. Harvey, R. M. Wellard, D. F. Abbott, V. Anderson, M. Kean, M. M. Saling, and G. D. Jackson
Language cortex activation in normal children
Neurology, September 28, 2004; 63(6): 1035 - 1044.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
F. Liegeois, A. Connelly, J. H. Cross, S. G. Boyd, D. G. Gadian, F. Vargha-Khadem, and T. Baldeweg
Language reorganization in children with early-onset lesions of the left hemisphere: an fMRI study
Brain, June 1, 2004; 127(6): 1229 - 1236.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
T Loddenkemper, D S Dinner, C Kubu, R Prayson, W Bingaman, A Dagirmanjian, and E Wyllie
Aphasia after hemispherectomy in an adult with early onset epilepsy and hemiplegia
J. Neurol. Neurosurg. Psychiatry, January 1, 2004; 75(1): 149 - 151.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
L. S. Medina, E. Aguirre, B. Bernal, and N. R. Altman
Functional MR Imaging versus Wada Test for Evaluation of Language Lateralization: Cost Analysis
Radiology, January 1, 2004; 230(1): 49 - 54.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
B. Bernal and N. R. Altman
Speech Delay in Children: A Functional MR Imaging Study
Radiology, December 1, 2003; 229(3): 651 - 658.
[Abstract] [Full Text] [PDF]

Home page
 Br Med BullHome page
N. Kapur and M. D Kopelman
Advanced brain imaging procedures and human memory disorder
Br. Med. Bull., March 1, 2003; 65(1): 61 - 81.
[Abstract] [Full Text] [PDF]

Home page
 Br Med BullHome page
M. P Richardson
Epilepsy and surgical mapping
Br. Med. Bull., March 1, 2003; 65(1): 179 - 192.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
A. Krainik, S. Lehericy, H. Duffau, L. Capelle, H. Chainay, P. Cornu, L. Cohen, A. -L. Boch, J. -F. Mangin, D. Le Bihan, et al.
Postoperative speech disorder after medial frontal surgery: Role of the supplementary motor area
Neurology, February 25, 2003; 60(4): 587 - 594.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
M. W.L. Chee and D. Caplan
Face encoding and psychometric testing in healthy dextrals with right hemisphere language
Neurology, December 24, 2002; 59(12): 1928 - 1934.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
W. D. Gaillard, L. Balsamo, B. Xu, C. B. Grandin, S. H. Braniecki, P. H. Papero, S. Weinstein, J. Conry, P. L. Pearl, B. Sachs, et al.
Language dominance in partial epilepsy patients identified with an fMRI reading task
Neurology, July 23, 2002; 59(2): 256 - 265.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
L. M. Balsamo, B. Xu, C. B. Grandin, J. R. Petrella, S. H. Braniecki, T. K. Elliott, and W. D. Gaillard
A Functional Magnetic Resonance Imaging Study of Left Hemisphere Language Dominance in Children
Arch Neurol, July 1, 2002; 59(7): 1168 - 1174.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
J. A. Maldjian, P. J. Laurienti, L. Driskill, and J. H. Burdette
Multiple Reproducibility Indices for Evaluation of Cognitive Functional MR Imaging Paradigms
AJNR Am. J. Neuroradiol., June 1, 2002; 23(6): 1030 - 1037.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
S. Lehericy, A. Biondi, N. Sourour, M. Vlaicu, S. T. du Montcel, L. Cohen, E. Vivas, L. Capelle, T. Faillot, A. Casasco, et al.
Arteriovenous Brain Malformations: Is Functional MR Imaging Reliable for Studying Language Reorganization in Patients? Initial Observations
Radiology, June 1, 2002; 223(3): 672 - 682.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
P. Jayakar, B. Bernal, L. Santiago Medina, and N. Altman
False lateralization of language cortex on functional MRI after a cluster of focal seizures
Neurology, February 12, 2002; 58(3): 490 - 492.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
L. Hertz-Pannier, C. Chiron, I. Jambaque, V. Renaux-Kieffer, P.-F. V. d. Moortele, O. Delalande, M. Fohlen, F. Brunelle, and D. L. Bihan
Late plasticity for language in a child's non-dominant hemisphere: A pre- and post-surgery fMRI study
Brain, February 1, 2002; 125(2): 361 - 372.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
J. H. Brannen, B. Badie, C. H. Moritz, M. Quigley, M. E. Meyerand, and V. M. Haughton
Reliability of Functional MR Imaging with Word-Generation Tasks for Mapping Broca's Area
AJNR Am. J. Neuroradiol., October 1, 2001; 22(9): 1711 - 1718.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
W. D. Gaillard, M. Pugliese, C. B. Grandin, S. H. Braniecki, P. Kondapaneni, K. Hunter, B. Xu, J. R. Petrella, L. Balsamo, and G. Basso
Cortical localization of reading in normal children: An fMRI language study
Neurology, July 10, 2001; 57(1): 47 - 54.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
R. L. Billingsley, M. P. McAndrews, A. P. Crawley, and D. J. Mikulis
Functional MRI of phonological and semantic processing in temporal lobe epilepsy
Brain, June 1, 2001; 124(6): 1218 - 1227.
[Abstract] [Full Text] [PDF]

Home page
 J Child NeurolHome page
J. I. Breier, P. G. Simos, J. W. Wheless, J. E.C. Constantinou, J. E. Baumgartner, V. Venkataraman, and A. C. Papanicolaou
Language Dominance in Children as Determined by Magnetic Source Imaging and the Intracarotid Amobarbital Procedure: A Comparison
J Child Neurol, February 1, 2001; 16(2): 124 - 130.
[Abstract] [PDF]

Home page
 BrainHome page
S. Knecht, B. Drager, M. Deppe, L. Bobe, H. Lohmann, A. Floel, E.-B. Ringelstein, and H. Henningsen
Handedness and hemispheric language dominance in healthy humans
Brain, December 1, 2000; 123(12): 2512 - 2518.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
S. Lehericy, L. Cohen, B. Bazin, S. Samson, E. Giacomini, R. Rougetet, L. Hertz-Pannier, D. Le Bihan, C. Marsault, and M. Baulac
Functional MR evaluation of temporal and frontal language dominance compared with the Wada test
Neurology, April 25, 2000; 54(8): 1625 - 1633.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1999 by AAN Enterprises, Inc.