HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bennett, J. L. Articles by Posner, J. B. Search for Related Content PubMed PubMed Citation Articles by Bennett, J. L. Articles by Posner, J. B.

Neuro-ophthalmologic manifestations of a paraneoplastic syndrome and testicular carcinoma

From the Departments of Neurology (Drs. Bennett and Galetta) and Pathology (Dr. Mourelatos), University of Pennsylvania School of Medicine, Philadelphia, PA; the Department of Ophthalmology and Neuroscience (Dr. Frohman), UMDNJ–New Jersey Medical School, Newark, NJ; and the Departments of Neurology (Drs. Gultekin, Dalmau, and Posner) and Pathology (Dr. Gultekin), Memorial Sloan–Kettering Cancer Center, New York, NY.Presented in part at the annual meeting of the American Academy of Neurology; Minneapolis, MN; April 1998.

Address correspondence and reprint requests to Dr. Steven L. Galetta, Department of Neurology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104.

The authors report two patients with testicular cancer who exhibited supranuclear gaze disorders as a manifestation of a paraneoplastic brainstem encephalomyelitis. In the first patient, neuro-ophthalmic dysfunction was accompanied by a prominent limbic encephalitis whereas in the second patient, an unusual, mixed pendular and jerk nystagmus was manifested. Neuroimaging revealed an enhancing hypothalamic mass in the first patient and was negative in the second. Blood from both patients contained an antibody previously reported in a patient with limbic encephalitis and testicular cancer.

This article has been cited by other articles:

				L A Hoffmann, S Jarius, H L Pellkofer, M Schueller, M Krumbholz, F Koenig, W Johannis, C la Fougere, T Newman, A Vincent, et al. Anti-Ma and anti-Ta associated paraneoplastic neurological syndromes: 22 newly diagnosed patients and review of previous cases J. Neurol. Neurosurg. Psychiatry, July 1, 2008; 79(7): 767 - 773. [Abstract] [Full Text] [PDF]

				J. Dalmau, F. Graus, A. Villarejo, J. B. Posner, D. Blumenthal, B. Thiessen, A. Saiz, P. Meneses, and M. R. Rosenfeld Clinical analysis of anti-Ma2-associated encephalitis Brain, August 1, 2004; 127(8): 1831 - 1844. [Abstract] [Full Text] [PDF]

				C. Thuerl, K. Muller, J. Laubenberger, B. Volk, and M. Langer MR Imaging of Autopsy-Proved Paraneoplastic Limbic Encephalitis in Non-Hodgkin Lymphoma AJNR Am. J. Neuroradiol., March 1, 2003; 24(3): 507 - 511. [Abstract] [Full Text] [PDF]

				S. H. Gultekin, M. R. Rosenfeld, R. Voltz, J. Eichen, J. B. Posner, and J. Dalmau Paraneoplastic limbic encephalitis: neurological symptoms, immunological findings and tumour association in 50 patients Brain, July 1, 2000; 123(7): 1481 - 1494. [Abstract] [Full Text] [PDF]

				R. Voltz, S. H. Gultekin, M. R. Rosenfeld, E. Gerstner, J. Eichen, J. B. Posner, and J. Dalmau A Serologic Marker of Paraneoplastic Limbic and Brain-Stem Encephalitis in Patients with Testicular Cancer N. Engl. J. Med., June 10, 1999; 340(23): 1788 - 1795. [Abstract] [Full Text] [PDF]