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Neurology 1999;52:1038
© 1999 American Academy of Neurology
Articles

Cerebral lateralization of language in normal left-handed people studied by functional MRI

Jesús Pujol, MD, Joan Deus, PhD, Josep M. Losilla, PhD and Antoni Capdevila, MD

From the Magnetic Resonance Center of Pedralbes (Drs. Pujol, Deus, and Capdevila), Barcelona; and the Department of Psychobiology and Methodology (Dr. Losilla), Autonomous University of Barcelona, Spain.

Address correspondence and reprint requests to Dr. Jesús Pujol, Magnetic Resonance Center of Pedralbes, Monestir, 3, 08034 Barcelona, Spain.

OBJECTIVE: To use functional MRI (fMRI) to further define the occurrence of left-hemisphere, bilateral, and right-hemisphere language in a normal left-handed population.

METHODS: A total of 100 healthy volunteers, consisting of 50 left-handed subjects and a reference group of 50 right-handed subjects, were studied by fMRI of the frontal cortex during silent word generation.

RESULTS: Ninety-six percent of right-handed subjects showed fMRI changes lateralized to the left hemisphere, whereas 4% showed a bilateral activation pattern. In contrast, left-hemisphere lateralization occurred in 76% of left-handers, bilateral activation in 14%, and right-hemisphere lateralization in the remaining 10%. The predominance of right-hemisphere activation, however, was weak in these cases; only a single left-handed subject (2%) showed complete right-hemisphere lateralization.

CONCLUSIONS: Silent word generation lateralizes to the left cerebral hemisphere in both handedness groups, but right-hemisphere participation is frequent in normal left-handed subjects. Exclusive right-hemisphere activation rarely occurred in the frontal lobe region studied.




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