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From the Department of Neuroscience, School of Medicine (Dr. Courchesne), and the Department of Cognitive Science (Dr. Müller), University of California, San Diego, La Jolla, CA; Laboratory for Research on the Neuroscience of Autism (Drs. Courchesne and Müller), Children’s Hospital Research Center, San Diego, CA; and Outpatient Department (Dr. Saitoh), National Center Hospital for Mental, Nervous, and Muscular Disorders, National Center for Neurology and Psychiatry, Tokyo, Japan.
Address correspondence and reprint requests to Dr. Eric Courchesne, Laboratory for Research on the Neuroscience of Autism, 8110 La Jolla Shores Dr., Room 201, La Jolla, CA 92037; e-mail: ecourchesne{at}ucsd.edu
The brain weights of 21 postmortem autism cases (5 new and 16 previously published) were compared with normal brain weights from six autopsy studies. Of the 21 cases, 17 had normal brain weights and 1 was micrencephalic. Compared with the normal median (1,460 g), three autism cases were megalencephalic: two (1,810 g and 1,820 g) had been previously reported and one (1,880 g) was a new case. Brain weight is thus normal in most postmortem cases of autism. There are, however, rare cases of megalencephaly and possibly micrencephaly.
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