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Neurology 1999;52:1067
© 1999 American Academy of Neurology
Brief Communications

()-{alpha}-[11C]Dihydro- tetrabenazine PET imaging in familial paroxysmal dystonic choreoathetosis

N. I. Bohnen, MD, PhD, R. L. Albin, MD, K. A. Frey, MD, PhD and J. K. Fink, MD

From the Departments of Internal Medicine, Division of Nuclear Medicine (Drs. Bohnen and Frey), and Neurology (Drs. Fink and Albin), The University of Michigan Medical School; and the Geriatric Research, Education and Clinical Center (Drs. Fink and Albin), Veterans Administration Medical Center, Ann Arbor, MI.

Address correspondence and reprint requests to Dr. Roger L. Albin, Neuroscience Laboratory Building, 1103 E. Huron, Ann Arbor, MI 48104-1687.

Clinical observations suggest a disturbance of striatal dopaminergic function in familial paroxysmal dystonic choreoathetosis (PDC). The authors used PET with [11C]dihydrotetrabenazine (DTBZ) to study striatal dopaminergic innervation in PDC. The results did not reveal abnormal DTBZ binding potential in PDC striatum. This suggests that dopaminergic abnormalities, if present, may be due to altered regulation of dopamine release or to postsynaptic mechanisms, rather than to an altered density of nigrostriatal innervation.




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S. Rainier, D. Thomas, D. Tokarz, L. Ming, M. Bui, E. Plein, X. Zhao, R. Lemons, R. Albin, C. Delaney, et al.
Myofibrillogenesis Regulator 1 Gene Mutations Cause Paroxysmal Dystonic Choreoathetosis
Arch Neurol, July 1, 2004; 61(7): 1025 - 1029.
[Abstract] [Full Text] [PDF]


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