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Neurology 1999;52:1069
© 1999 American Academy of Neurology
Brief Communications

Effect of interferon ß on human myelin basic protein–specific T-cell lines: Comparison of IFNß-1a and IFNß-1b

F. Weber, MD, J. Janovskaja, T. Polak, MD, S. Poser, MD and P. Rieckmann, MD

From the Department of Neurology (Drs. Weber, Polak, and Poser, and J. Janovskaja), Georg-August-University of Göttingen; and the Department of Neurology (Dr. Rieckmann), Julius-Maximilians-University of Würzburg, Germany.

Address correspondence and reprint requests to Dr. F. Weber, Department of Neurology, University of Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany.

The effect of interferon (IFN)ß-1a and IFNß-1b on human myelin basic protein-reactive T-cell lines was investigated. Both drugs inhibited proliferation and production of lymphotoxin (LT), whereas the production of interleukin-4 was not altered and interleukin-10 was induced. Comparing equal numbers of units IFNß-1a and -1b showed almost identical results. These in vitro data indicate that the immunomodulatory capacity of both interferons with respect to T cells paralleled their antiviral effect.




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G. Francis, F. Weber, and P. Rieckmann
Effect of interferon {beta} on human myelin basic protein-specific T-cell lines: Comparison of IFN{beta}-1a and IFN{beta}-1b
Neurology, July 25, 2000; 55(2): 322 - 323.
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