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Neurology 1999;52:1485
© 1999 American Academy of Neurology
Brief Communications

Elevated frequencies of natural killer T lymphocytes in myasthenia gravis

Carsten Reinhardt, MD and Arthur Melms, MD

From the Department of Neurology (Drs. Reinhardt and Melms), Eberhard-Karls-University, Tübingen; and Max Planck Institute of Psychiatry (Dr. Reinhardt), Munich, Germany.

Address correspondence and reprint requests to Dr. Carsten Reinhardt, Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804 Munich, Germany; e-mail: reinhard{at}mpipsykl.mpg.de

T lymphocytes are considered to exert a regulatory function in the development of antiacetylcholine receptor antibodies, but no clear T-cell alterations in patients with myasthenia gravis (MG) have yet been found. The authors report a significant increase of recently identified natural killer T lymphocytes expressing T-cell receptor V{alpha}24. A possible role in disease initiation or maintenance is suggested by the observed strong synthesis of interferon-{gamma} as well as of interleukin 4.




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