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Neurology 1999;52:1497
© 1999 American Academy of Neurology
Brief Communications

FK506-induced leukoencephalopathy in children with organ transplants

H. V. Torocsik, DO, R. G. Curless, MD, J. Post, MD, A. G. Tzakis, MD and L. Pearse, MD

From the Departments of Neurology (Drs. Torocsik and Curless), Radiology (Dr. Post), Liver Transplant (Dr. Tzakis), and Cardiac Transplant (Dr. Pearse), University of Miami School of Medicine, FL.

Address correspondence and reprint requests to Dr. Richard G. Curless, Department of Neurology (D4-5), PO Box 016960, Miami, FL 33101.

FK506-induced leukoencephalopathy is a well-known entity in adult organ transplant patients. The neurotoxicity of FK506 immunosuppression is frequently reversible, with either reduction or cessation of the drug. This neurologic syndrome is not well documented in children. We report the clinical and radiologic features in four pediatric cases of FK506 leukoencephalopathy. In two of the four patients this syndrome was reversible.




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