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Neurology 1999;52:1507
© 1999 American Academy of Neurology
Brief Communications

Intranasal sumatriptan for the acute treatment of migraine in children

Michael A. Ueberall, MD and Dieter Wenzel, MD

From the Neuropediatric Department, University Hospital for Children and Adolescents, Loschgestraße 15, Erlangen, Germany.

Address correspondence and reprint requests to Dr. Michael A. Ueberall, Neuropediatric Department, University Hospital for Children and Adolescents, Loschgestraße 15, 91054 Erlangen, Germany; e-mail: Michael.Ueberall{at}kinder.med.uni-erlangen.de

Sumatriptan is a highly effective treatment for migraine in adults but its efficacy in children has not been determined. Fourteen children with migraine (6.4 to 9.8 years of age; seven girls, six with aura) participated in a randomized double-blind placebo-controlled crossover study to evaluate the efficacy of sumatriptan nasal spray. After sumatriptan, 12 of 14 (versus 6 of 14 after placebo) reported a decrease in pain intensity (p = 0.031); complete headache relief was obtained in 9 of 14 after sumatriptan versus 2 of 14 after placebo (p = 0.016). Migraine-associated symptoms were also significantly reduced by sumatriptan.




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