HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Grote, C. L. Articles by Greenlee, W. Search for Related Content PubMed PubMed Citation Articles by Grote, C. L. Articles by Greenlee, W.

Wada difference a day makes

Interpretive cautions regarding same-day injections

From the Departments of Psychology (Dr. Grote and C. Wierenga), Neurological Sciences (Drs. Smith, Kanner, and Bergen), and Diagnostic Radiology (Drs. Geremia and Greenlee), Rush-Presbyterian-St. Luke’s Medical Center, Chicago, IL.

Address correspondence and reprint requests to Dr. C.L. Grote, Department of Psychology, Rush-Presbyterian-St. Luke’s Medical Center, Chicago, IL 60612.

OBJECTIVE: To determine whether memory scores after second intracarotid amobarbital procedure (IAP) injections are affected by the time between the first and second injections.

METHODS: Sixty-two patients received their second IAP injection on the day after the first injection. Forty-three other patients received the second injection on the same day as the first injection. Both groups underwent similar IAP protocols and memory assessments, except for the timing of the second injection.

RESULTS: The second IAP memory scores in the two-day group were significantly higher (p < 0.05) than those in the one-day group. Timing of second injection was a significant correlate of second memory scores, but amobarbital dosage, first IAP memory score, and pre-IAP measures of memory and intelligence were not significant correlates.

CONCLUSION: One-day and two-day IAP protocols do not result in similar memory scores after the second injection. Nineteen percent of a subset of patients in the one-day protocol were misclassified, in terms of IAP memory ratings, because of the deleterious effect of having both injections on the same day. It is recommended that correction scores be considered, for some patients who receive two IAP injections on one day, to approximate what the second IAP memory score would have been had the second injection occurred on a second day.

This article has been cited by other articles:

				H. E. Kirsch, J. A. Walker, F. S. Winstanley, R. Hendrickson, S.T.C. Wong, N. M. Barbaro, K. D. Laxer, and P. A. Garcia Limitations of Wada memory asymmetry as a predictor of outcomes after temporal lobectomy Neurology, September 13, 2005; 65(5): 676 - 680. [Abstract] [Full Text] [PDF]

				A. G. Wood, A. S. Harvey, R. M. Wellard, D. F. Abbott, V. Anderson, M. Kean, M. M. Saling, and G. D. Jackson Language cortex activation in normal children Neurology, September 28, 2004; 63(6): 1035 - 1044. [Abstract] [Full Text] [PDF]

				T. Bengner, H. Haettig, M. Merschhemke, C. Dehnicke, and H. J. Meencke Memory assessment during the intracarotid amobarbital procedure: Influence of injection order Neurology, December 9, 2003; 61(11): 1582 - 1587. [Abstract] [Full Text] [PDF]

				K. J. Meador and D. W. Loring The Wada test Neurology, May 1, 1999; 52(8): 1535 - 1535. [Full Text]