Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Urbach, H.
Right arrow Articles by Elger, C. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Urbach, H.
Right arrow Articles by Elger, C. E.
Neurology 1999;52:1596
© 1999 American Academy of Neurology
Articles

Amobarbital effects on the posterior hippocampus during the intracarotid amobarbital test

H. Urbach, MD, M. Kurthen, MD, E. Klemm, MD, T. Grunwald, MD, PhD, D. Van Roost, MD, D. B. Linke, MD, H. J. Biersack, MD, J. Schramm, MD and C. E. Elger, MD

From the Department of Neuroradiology (Dr. Urbach), Epileptology (Drs. Kurthen, Grunwald, and Elger), Nuclear Medicine (Drs. Klemm and Biersack), and Neurosurgery (Drs. Van Roost, Linke, and Schramm), University of Bonn, Germany.

Address correspondence and reprint requests to Dr. H. Urbach, Department of Neuroradiology, University of Bonn, Sigmund Freud-Strasse 25, D-53105 Bonn, Germany.

OBJECTIVE: To relate functional effects on the hippocampus during the intracarotid amobarbital test (IAT) to its direct perfusion with amobarbital.

METHODS: In 17 patients with intractable temporal lobe epilepsy, 28 hemispheres were perfused with 2.3 mL of 10% solution of 200 mg amobarbital and 37 MBq 99mTc-hexamethylpropylene amine oxime (HMPAO). For evaluation of amobarbital effects, data were combined from stereo-EEG (S-EEG) recordings from intrahippocampal depth electrodes and high-resolution SPECT after intracarotid injection of HMPAO.

RESULTS: Perfusion of the entire hippocampus was observed only in hemispheres with a fetal origin of the posterior cerebral artery (PCA). In 10 hemispheres, S-EEG recordings could not unequivocally be assigned to either the anterior or the posterior part of the hippocampus. In the remaining 18 hemispheres, only the two with a fetal type of PCA showed perfusion of the entire hippocampus. In both, hippocampal electrical activity changed under the influence of amobarbital but did not differ in anterior and posterior contacts. In 15 of 16 hemispheres in which SPECT demonstrated perfusion of the anterior hippocampus only, amobarbital injection resulted in significant S-EEG activity change in both the anterior and the posterior parts of the hippocampus.

CONCLUSION: S-EEG effects on the posterior hippocampus during the IAT can occur without direct perfusion of those brain areas.




This article has been cited by other articles:


Home page
 NeurologyHome page
X. Setoain, S. Arroyo, F. Lomena, J. Pavia, D. Pareto, T. Boget, N. Bargallo, J. Rumia, D. Fuster, S. Fuertes, et al.
Can the Wada test evaluate mesial temporal function?: A SPECT study
Neurology, June 22, 2004; 62(12): 2241 - 2246.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
K. J. Meador and D. W. Loring
The Wada test
Neurology, May 1, 1999; 52(8): 1535 - 1535.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1999 by AAN Enterprises, Inc.