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From the Unit of Clinical Neuroimmunology, Hospital Vall d’Hebron, Barcelona, Spain.
Address correspondence and reprint requests to Cecília Borràs, Unit of Clinical Neuroimmunology, Escola d’Infermeria, 5a planta, Hospital Vall d’Hebron, Pssg, Vall d’Hebron, 119-129, 08035 Barcelona, Spain; e-mail: cborras{at}hg.vhebron.es
BACKGROUND: Depression has been cited as a possible side effect of interferon beta-1b (IFNß-1b) therapy in patients with MS. This association remains unproven because of a lack of longitudinal studies.
OBJECTIVE: To determine the changes in emotional state in relapsing-remitting (RR) MS patients during the first 2 years of treatment with IFNß-1b.
METHODS: Emotional state was evaluated in a sample of 90 patients at the onset of IFNß-1b treatment during an inclusion period of 2.5 years. Seventy-five patients were evaluated at their 12th month of treatment and 56 patients at their 24th month. We assessed their emotional state with the following psychological tests: Hamilton Depression Rating Scale, Beck Depression Inventory, and State-Trait Anxiety Inventory.
RESULTS: We found significant improvement in emotional state after the first and second years of treatment.
CONCLUSIONS: Our findings show that IFNß-1b does not increase depression or anxiety in RR MS patients during the first and second years of IFNß-1b treatment. In fact, slight but significant improvement in depression and anxiety symptoms was observed during this period.
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