HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Blumenthal, D. T. Articles by Abrey, L. E. Search for Related Content PubMed PubMed Citation Articles by Blumenthal, D. T. Articles by Abrey, L. E.

Primary intracranial neoplasms in patients with HIV

From the Department of Neurology (Dr. Blumenthal), University of Utah School of Medicine, Salt Lake City, UT; the Departments of Neurology (Drs. Raizer and Abrey), Neurosurgery (Dr. Bilsky), and Pathology (Dr. Rosenblum), Memorial Sloan-Kettering Cancer Center, New York, NY; and the New Jersey Neuroscience Institute (Dr. Hariharan), JFK Medical Center, Edison, NJ.

Address correspondence and reprint requests to Dr. Lauren E. Abrey, Department of Neurology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021; e-mail: abreyl{at}mskcc.org

OBJECTIVE: To report a series of HIV-infected patients with intracranial tumors not known to be associated with immunodeficiency.

BACKGROUND: The spectrum of HIV-associated diseases is changing with improved treatments and prolonged patient survival. Although primary central nervous system lymphoma (PCNSL) and toxoplasmosis continue to be the most common intracranial lesions in HIV-infected patients, the recognition of other pathologic entities is increasingly important.

METHODS: The clinical characteristics and outcome of eight HIV-infected patients with nine intracranial neoplasms other than PCNSL are reported. In addition, all available pathologic specimens were tested for evidence of either HIV or Epstein-Barr virus (EBV) infection. An additional 28 patients reported in the literature are summarized.

RESULTS: Five of eight patients had a glioblastoma multiforme; other tumors included an anaplastic ependymoma, a low-grade glioma, a subependymoma, and a leiomyosarcoma. More than half of the patients developed their tumor 6 years after the diagnosis of HIV infection. Patient prognosis and survival was best predicted by tumor histology. Treatment response and outcome did not appear to be influenced by HIV infection. Only the leiomyosarcoma demonstrated evidence of latent EBV infection.

CONCLUSIONS: HIV-infected patients are at risk for intracranial neoplasms other than PCNSL, and benefit from aggressive tumor-specific therapy. It is possible that gliomas are occurring at a higher rate than in the general population. There was no evidence of HIV or EBV infection in any glial tumor.

This article has been cited by other articles:

				R. Harrod, J. Nacsa, C. Van Lint, J. Hansen, T. Karpova, J. McNally, and G. Franchini Human Immunodeficiency Virus Type-1 Tat/Co-activator Acetyltransferase Interactions Inhibit p53Lys-320 Acetylation and p53-responsive Transcription J. Biol. Chem., March 28, 2003; 278(14): 12310 - 12318. [Abstract] [Full Text] [PDF]

				D. Schiff, B. O'Neill, E. Wijdicks, J. H. Antin, and P. Y. Wen Gliomas arising in organ transplant recipients: An unrecognized complication of transplantation? Neurology, October 23, 2001; 57(8): 1486 - 1488. [Abstract] [Full Text] [PDF]