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Neurology 1999;52:1687
© 1999 American Academy of Neurology
Brief Communications

Correlation between rates of brain atrophy and cognitive decline in AD

N. C. Fox, MRCP, R. I. Scahill, MA, W. R. Crum, PhD and M. N. Rossor, FRCP

From the Dementia Research Group (N. Fox, R. Scahill, Dr. Crum, and M. Rossor), Department of Clinical Neurology, Institute of Neurology, University College; and Imperial College School of Medicine (M. Rossor), London, UK.

Address correspondence and reprint requests to Prof. Martin N. Rossor, Dementia Research Group, The National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG UK; e-mail: nfox{at}dementia.ion.ucl.ac.uk

Twenty-nine untreated patients diagnosed with probable AD and 15 control patients underwent two or more clinical and volumetric MRI assessments with intervals ranging from 5 months to 6 years. The change in global cerebral volume for an individual was calculated by a novel method of registration and subtraction of serial scans. Rate of global cerebral volume loss correlated strongly with rate of change in Mini-Mental State Examination scores (r = 0.80, p < 0.001), implying clinical relevance to this marker of progression.




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