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ACTH versus vigabatrin therapy in infantile spasms: A retrospective study

From the Department of Pediatrics (Neurology) (Drs. Cossette and Carmant), Université de Montréal, Hôpital Sainte-Justine, Montréal, Québec, Canada; and Department of Neurology (Dr. Riviello), Harvard Medical School, Children’s Hospital, Boston, MA.

Address correspondence and reprint requests to Dr. Lionel Carmant, Service de Neurologie, Hôpital Sainte-Justine, 3175, Côte Sainte-Catherine, Montréal, Qc, H3T 1C5 Canada; e-mail: carmantl{at}ere.umontreal.ca

ACTH is the standard treatment for infantile spasms (IS) in North America. Recent reports showed that vigabatrin is a valuable treatment for IS, but comparative studies with ACTH are limited. In this study, we compare the effectiveness of ACTH versus vigabatrin on IS. Our results support that vigabatrin is as effective as and better tolerated than ACTH. Because of their similar efficacy, we believe that vigabatrin should be the first intention drug for the treatment of IS.

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