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Neurology 1999;52:1708
© 1999 American Academy of Neurology
Brief Communications

Oral cyclosporine decreases severity of neurotoxicity in liver transplant recipients

Eelco F. M. Wijdicks, MD, Linda J. Dahlke, RN and Russell H. Wiesner, MD

From the Department of Neurology and Division of Liver Transplantation, Mayo Clinic and Mayo Foundation, Rochester, MN.

Address correspondence and reprint requests to Dr. E.F.M. Wijdicks, Department of Neurology, Mayo Clinic, W8A, 200 First Street SW, Rochester, MN 55905.

Neoral is a new formulation of cyclosporine that permits reliable absorption in patients with external biliary drainage. The authors reviewed 227 liver transplant patients receiving primary treatment with Neoral. Headache occurred in 24 patients (11%), mild tremors in 12 patients, paresthesia in 5 patients, acute confusional state in 4 patients, and seizures in 2 patients. It is apparent that Neoral has profoundly reduced the severity of neurotoxicity in liver transplant recipients.




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